Selected Dervan Lab Publications

Number
Title, Authors
Journal Volume, Pages (Year)
"Antitumor Activity of a Pyrrole-imidazole Polyamide," Fei Yang, Nicholas G. Nickols, Benjamin C. Li, Georgi K. Marinov, Jonathan W. Said, Peter B. Dervan.
Proc. Natl. Acad. Sci. USA 110, 1863-1868 (2013).
"Pyrrole-Imidazole Polyamides Distinguish Between Double-Helical DNA and RNA," David M. Chenoweth, Jordan L. Meier, Peter B. Dervan.
Angew. Chem. Int. Ed 52, 415-418 (2013).
"Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide," Jevgenij A. Raskatov, Nicholas G. Nickols, Amanda E. Hargrove, Georgi K. Marinov, Barbara Wold, Peter B. Dervan.
Proc. Natl. Acad. Sci. USA 109, 16041-16045 (2012).
"Microwave Assisted Synthesis of Py-Im Polyamides," James W. Puckett, Joshua T. Green, Peter B. Dervan.
Org. Lett 14, 2774-2777 (2012).
"Pharmacokinetics of Py-Im Polyamides Depend on Architecture: Cyclic versus Linear," Jevgenij A. Raskatov, Amanda E. Hargrove, Alex Y. So, Peter B. Dervan.
J. Am. Chem. Soc. 134, 7995–7999 (2012).
"Allosteric modulation of DNA by small molecules," David M. Chenoweth, Peter B. Dervan.
Proc. Natl. Acad. Sci. USA 106, 13175-13179 (2009).
"In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography," Daniel A. Harki, Nagichettiar Satyamurthy, David B. Stout, Michael E. Phelps, Peter B. Dervan.
Proc. Natl. Acad. Sci. USA 105, 13039-13044 (2008).
"Modulating Hypoxia-Inducible Transcription by Disrupting the HIF-1–DNA Interface," Nicholas G. Nickols, Claire S. Jacobs, Michelle E. Farkas, Peter B. Dervan.
ACS Chem. Biol. 2, 561-571 (2007).
"Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide," Nicholas G. Nickols, Peter B. Dervan.
Proc. Natl. Acad. Sci. USA 104, 10418-10423 (2007).
"Regulation of Gene Expression by Synthetic DNA-Binding Ligands," Peter B. Dervan, Adam T. Poulin-Kerstien, Eric J. Fechter, Benjamin S. Edelson.
Top. Curr. Chem. 253, 1-31 (2005).
"Molecular recognition of the nucleosomal "supergroove"," Rajeswari S. Edayathumangalam, Philipp Weyermann, Joel M. Gottesfeld, Peter B. Dervan, Karolin Luger.
Proc. Natl. Acad. Sci. USA 101, 6864-6869 (2004).
"DNA-Templated Dimerization of Hairpin Polyamides," Adam T. Poulin-Kerstien, Peter B. Dervan.
J. Am. Chem. Soc. 125, 15811-15821 (2003).
"Toward Artificial Developmental Regulators," Hans-Dieter Arndt, Karl E. Hauschild, David P. Sullivan, Kara Lake, Peter B. Dervan, Aseem Z. Ansari.
J. Am. Chem. Soc. 125, 13322-13323 (2003).
"Nuclear localization of pyrrole-imidazole polyamide-fluorescein conjugates in cell culture," Timothy P. Best, Benjamin S. Edelson, Nicholas G. Nickols, Peter B. Dervan.
Proc. Natl. Acad. Sci. USA 100, 12063-12068 (2003).
"Recognition of the DNA minor groove by pyrrole-imidazole polyamides," Peter B. Dervan, Benjamin S. Edelson.
Curr. Opin. Struc. Biol. 13, 284-299 (2003).
"Imidazopyridine/Pyrrole and Hydroxybenzimidazole/Pyrrole Pairs for DNA Minor Groove Recognition," Dorte Renneberg, Peter B. Dervan.
J. Am. Chem. Soc. 125, 5707-5716 (2003).
"Crystal Structures of Nucleosome Core Particles in Complex with Minor Groove DNA-binding Ligands," Robert K. Suto, Rajeswari S. Edayathumangalam, Cindy L. White, Christian Melander, Joel M. Gottesfeld, Peter B. Dervan, Karolin Luger.
J. Mol. Biol. 326, 371-380 (2003).
"Molecular Recognition of DNA by Small Molecules," Peter B. Dervan.
Bioorg. Med. Chem. 9, 2215-2235 (2001).
"Towards a minimal motif for artificial transcriptional activators," Aseem Z. Ansari, Anna K. Mapp, Doan H. Nguyen, Peter B. Dervan, Mark Ptashne.
Chem. Biol. 8, 583-592 (2001).
"Toward rules for 1:1 polyamide:DNA recognition," Adam R. Urbach, Peter B. Dervan.
Proc. Natl. Acad. Sci. USA 98, 4343-4348 (2001).
"Activation of gene expression by small molecule transcription factors," Anna K. Mapp, Aseem Z. Ansari, Mark Ptashne, Peter B. Dervan.
Proc. Natl. Acad. Sci. USA 97, 3930-3935 (2000).
"Tandem Hairpin Motif for Recognition in the Minor Groove of DNA by Pyrrole-Imidazole Polyamides," David M. Herman, Eldon E. Baird, Peter B. Dervan.
Chem. Eur. J. 5, 975-983 (1999).
"Cycle Polyamide Motif for Recognition of the Minor Groove of DNA," David M. Herman, James M. Turner, Eldon E. Baird, Peter B. Dervan.
J. Am. Chem. Soc. 121, 1121-1129 (1999).
"Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands," Liliane A. Dickinson, Richard J. Gulizia, John W. Trauger, Eldon E. Baird, Donald E. Mosier, Joel M. Gottesfeld, Peter B. Dervan.
Proc. Natl. Acad. Sci. USA 95, 12890-12895 (1998).
"A Structural Basis for Recognition of A·T and T·A Base Pairs in the Minor Groove of B-DNA," Clara L. Kielkopf, Sarah White, Jason W. Szewczyk, James M. Turner, Eldon E. Baird, Peter B. Dervan, Douglas C. Rees.
Science 282, 111-115 (1998).
"Structural basis for G·C recognition in the DNA minor groove," Clara L. Kielkopf, Eldon E. Baird, Peter B. Dervan, Douglas C. Rees.
Nat. Struct. Biol. 5, 104-109 (1998).
"Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands," Sarah White, Jason W. Szewczyk, James M. Turner, Eldon E. Baird, Peter B. Dervan.
Nature 391, 468-471 (1998).
"Regulation of gene expression by small molecules," Joel M. Gottesfeld, Laura Neely, John W. Trauger, Eldon E. Baird, Peter B. Dervan.
Nature 387, 202-205 (1997).
"Recognition of DNA by designed ligands at subnanomolar concentrations," John W. Trauger, Eldon E. Baird, Peter B. Dervan.
Nature 382, 559-561 (1996).
"Solid Phase Synthesis of Polyamides Containing Imidazole and Pyrrole Amino Acids," Eldon E. Baird, Peter B. Dervan.
J. Am. Chem. Soc. 118, 6141-6146 (1996).
"Hairpin Peptide Motif. A New Class of Oligopeptides for Sequence-Specific Recognition in the Minor Groove of Double-Helical DNA," Milan Mrksich, Michelle E. Parks, Peter B. Dervan.
J. Am. Chem. Soc. 116, 7983-7988 (1994).
"Design of Peptides That Bind in the Minor Groove of DNA at 5'-(A,T)G(A,T)C(A,T)-3' Sequences by a Dimeric Side-by-Side Motif," Warren S. Wade, Milan Mrksich, Peter B. Dervan.
J. Am. Chem. Soc. 114, 8783-8794 (1992).
"Antiparallel side-by-side dimeric motif for sequence-specific recognition in the minor groove of DNA by the designed peptide 1-methylimidazole-2-carboxamide netropsin," Milan Mrksich, Warren S. Wade, Tammy J. Dwyer, Bernhard H. Geierstanger, David E. Wemmer, Peter B. Dervan.
Proc. Natl. Acad. Sci. USA 89, 7586-7590 (1992).
"Sequence-Specific Double-Strand Alkylation and Cleavage of DNA Mediated by Triple-Helix Formation," Thomas J. Povsic, Scott A. Strobel, Peter B. Dervan.
J. Am. Chem. Soc. 114, 5934-5941 (1992).
"Site-Specific Cleavage of Human Chromosome 4 Mediated by Triple-Helix Formation," Scott A. Strobel, Lynn A. Doucette-Stamm, Laura Riba, David E. Housman, Peter B. Dervan.
Science 254, 1639-1642 (1991).
"Second Structural Motif for Recognition of DNA by Oligonucleotide-Directed Triple-Helix Formation," Peter A. Beal, Peter B. Dervan.
Science 251, 1360-1363 (1991).
"Recognition of Mixed-Sequence Duplex DNA by Alternate-Strand Triple-Helix Formation," David A. Horne, Peter B. Dervan.
J. Am. Chem. Soc. 112, 2435-2437 (1990).
"Inhibition of DNA Binding Proteins by Oligonucleotide-Directed Triple Helix Formation," Louis J. Maher III, Barbara Wold, Peter B. Dervan.
Science 245, 725-730 (1989).
"Synthesis of a Sequence-Specific DNA-Cleaving Peptide," James P. Sluka, Suzanna J. Horvath, Michael F. Bruist, Melvin I. Simon, Peter B. Dervan.
Science 238, 1129-1132 (1987).
"Sequence-Specific Cleavage of Double Helical DNA by Triple Helix Formation," Heinz E. Moser, Peter B. Dervan.
Science 238, 645-650 (1987).
"Sequence-specific cleavage of single-stranded DNA: Oligodeoxynucleotide-EDTA·Fe(II)," Geoffrey B. Dreyer, Peter B. Dervan.
Proc. Natl. Acad. Sci. USA 82, 968-972 (1985).
"DNA Affinity Cleaving. Sequence Specific Cleavage of DNA by Distamycin-EDTA·Fe(II) and EDTA-Distamycin·Fe(II)," John S. Taylor, Peter G. Schultz, Peter B. Dervan.
Tetrahedron 40, 457-465 (1984).
"Design and Synthesis of a Sequence-Specific DNA Cleaving Molecule. (Distamycin-EDTA)iron(II)," Peter G. Schultz, John S. Taylor, Peter B. Dervan.
J. Am. Chem. Soc. 104, 6861-6863 (1982).
"Map of distamycin, netropsin, and actinomycin binding sites on heterogeneous DNA: DNA cleavage-inhibition patterns with methidiumpropyl-EDTA·Fe(II)," Michael W. Van Dyke, Robert P. Hertzberg, Peter B. Dervan.
Proc. Natl. Acad. Sci. USA 79, 5470-5474 (1982).
"Cleavage of Double Helical DNA by (Methidiumpropyl-EDTA)iron(II)," Robert P. Hertzberg, Peter B. Dervan.
J. Am. Chem. Soc. 104, 313-315 (1982).
"Molecular Recognition of DNA by Small Molecules. Synthesis of Bis(methidium)spermine, a DNA Polyintercalating Molecule," Peter B. Dervan, Michael M. Beckker.
J. Am. Chem. Soc. 100, 1968-1970 (1978).