Publications

Selected Publications

361 "Sequence specific suppression of androgen receptor–DNA binding in vivo by a Py-Im polyamide," Alexis A. Kurmis, Peter B. Dervan.

Nucleic Acids Res., 47, 3828–3835, (2019).

360 "A Personal Perspective on Chemical Biology: Before the Beginning," Peter B. Dervan.

Isr. J. Chem., 59, 71-83, (2019).

359 "Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide," Silvia Diaz-Perez, Nathanael Kane, Alexis A. Kurmis, Fei Yang, Nicolas T. Kummer, Peter B. Dervan, Nicholas G. Nickols.

PLoS One, 13, e0196803, (2018).

358 "Molecular Recognition of DNA by Py-Im Polyamides: From Discovery to Oncology," Peter B. Dervan, Alexis A. Kurmis, Paul B. Finn.

DNA-targeting Molecules as Therapeutic Agents, 7, 298-331, M. J. Waring, Ed., RSC, CPI Group (UK) LTD, Croydon, United Kingdom, (2018).

357 "Structural Basis for the Initiation of Eukaryotic Transcription-Coupled DNA Repair.," Jun Xu, Indrajit Lahiri, Wei Wang, Adam Wier, Michael A. Cianfrocco, Jenny Chong, Alissa A. Hare, Peter B. Dervan, Frank DiMaio, Andres E. Leschziner, Dong Wang.

Nature, 551, 653-657, (2017).

356 "A Pyrrole-imidazole Polyamide is Active Against Enzalutamide-resistant Prostate Cancer," Alexis A. Kurmis, Fei Yang, Timothy R. Welch, Nickolas G. Nickols, Peter B. Dervan.

Cancer Res., 77, 2207-2212, (2017).

355 "RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif," Liang Xu, Wei Wang, Deanna Gotte, Fei Yang, Alissa A. Hare, Timothy R. Welch, Benjamin C. Li, Ji H. Shin, Jenny Chong, Jeffrey N. Strathern, Peter B. Dervan, Dong Wang.

Proc. Natl. Acad. Sci. USA, 113, 12426-12431, (2016).

354 "Stalled DNA Replication Forks at the Endogenous GAA Repeats Drive Repeat Expansion in Friedreich's Ataxia Cells," Jeannine Gerhardt, Angela D. Bhalla, Jill S. Butler, James W. Puckett, Peter B. Dervan, Zev Rosenwaks, Marek Napierala.

Cell Reports, 16, 1218-1227, (2016).

353 "A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity," Veena S. Mysore, Jerzy O. Szablowski, Peter B. Dervan, Patrick J. Frost.

Mol. Cancer Res., 14, 253-266, (2016).

352 "An HRE-Binding Py-Im Polyamide Impairs Hypoxic Signaling in Tumors," Jerzy O. Szablowski, Jevgenij A. Raskatov, Peter B. Dervan.

Mol. Cancer Ther., 15, 608-617, (2016).

351 "Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide," Amanda E. Hargrove, Thomas F. Martinez, Alissa A. Hare, Alexis A. Kurmis, John W. Phillips, Sudha Sud, Kenneth J. Pienta, Peter B. Dervan.

PLOS ONE, 10, e0143161, (2015).

350 "A Sequence-specific DNA Binding Small Molecule Triggers the Release of Immunogenic Signals and Phagocytosis in a Model of B-cell Lymphoma," JeenJoo S. Kang, Peter B. Dervan.

Q. Rev. Biophys., 48, 453-464, (2015).

349 "Tumor Xenograft Uptake of a Pyrrole-Imidazole (Py-Im) Polyamide Varies as a Function of Cell Line Grafted," Jevgenij A. Raskatov, Jerzy O. Szablowski, Peter B. Dervan.

J. Med. Chem., 57, 8471-8476, (2014).

348 "Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response," Thomas F. Martinez, John W. Phillips, Kenneth K. Karanja, Piotr Polaczek, Chieh-Mei Wang, Benjamin C. Li, Judith L. Campbell, Peter B. Dervan.

Nucleic Acids Res., 42, 11546-11559, (2014).

347 "A C-14 Labeled Py-Im Polyamide Localizes to a Subcutaneous Prostate Cancer Tumor.," Jevgenij A. Raskatov, James W. Puckett, Peter B. Dervan.

Bioorg. Med. Chem., 22, 4371-4375, (2014).

346 "Design of a Hairpin Py-Im Polyamide for DNA Methyltransferase Inhibition," JeenJoo S. Kang, Jordan L. Meier, Peter B. Dervan.

J. Am. Chem. Soc., 136, 3687-3694, (2014).

345 "Animal Toxicity of Hairpin Pyrrole-Imidazole Polyamides Varies with the Turn Unit," Fei Yang, Nicholas G. Nickols, Benjamin C. Li, Jerzy O. Szablowski, Shari R. Hamilton, Jordan L. Meier, Chieh-Mei Wang, Peter B. Dervan.

J. Med. Chem., 56, 7449-7457, (2013).

344 "Activity of a Py-Im Polyamide Targeted to the Estrogen response Element," Nicholas G. Nickols, Jerzy O. Szablowski, Amanda E. Hargrove, Benjamin C. Li, Jevgenij A. Raskatov, Peter B. Dervan.

Mol. Cancer Ther., 12, 675-684, (2013).

343 "Molecular basis of anitibiotic multiresistance transfer in Staphylococcus aureus," Jonathan S. Edwards, Laurie Betts, Monica L. Frazier, Rebecca M. Pollet, Stephen M. Kwong, William G. Walton, W. Keith Ballentine III, Juianne J. Huang, Sohrab Habibi, Mark Del Campo, Jordan L. Meier, Peter B. Dervan, Neville Firth, Matthew R. Redinbo.

Proc. Natl. Acad. Sci. USA, 110, 2804-2809, (2013).

342 "Antitumor Activity of a Pyrrole-imidazole Polyamide," Fei Yang, Nicholas G. Nickols, Benjamin C. Li, Georgi K. Marinov, Jonathan W. Said, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 110, 1863-1868, (2013).

341 "Synthesis of Cyclic Py-Im Polyamide Libraries," Benjamin C. Li, David C. Montgomery, James W. Puckett, Peter B. Dervan.

J. Org. Chem, 78, 124-133, (2013).

340 "Pyrrole-Imidazole Polyamides Distinguish Between Double-Helical DNA and RNA," David M. Chenoweth, Jordan L. Meier, Peter B. Dervan.

Angew. Chem. Int. Ed, 52, 415-418, (2013).

339 "Guiding the Design of Synthetic DNA-Binding Molecules with Massively Parallel Sequencing," Jordan L. Meier, Abigail S. Yu, Ian Korf, David J. Segal, Peter B. Dervan.

J. Am. Chem. Soc., 134, 17814-17822, (2012).

338 "Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide," Jevgenij A. Raskatov, Nicholas G. Nickols, Amanda E. Hargrove, Georgi K. Marinov, Barbara Wold, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 109, 16041-16045, (2012).

337 "Single-dose pharmacokinetic and toxicity analysis of pyrrole–imidazole polyamides in mice," Timothy W. Synold, Bixin Xi, Jun Wu, Yun Yen, Benjamin C. Li, Fei Yang, John W. Phillips, Nicholas G. Nickols, Peter B. Dervan.

Cancer Chemoth. Pharm., 70, 617-625, (2012).

336 "Role of mismatch repair enzymes in GAA•TTC triplet-repeat expansion in Friedreich's ataxia induced pluripotent stem cells," Jintang Du, Erica Campau, Elisabetta Soragni, Sherman Ku, James W. Puckett, Peter B. Dervan, Joel M. Gottesfeld.

J. Biol. Chem., 287, 29861–29872, (2012).

335 "Characterization and solubilization of pyrrole-imidazole polyamide aggregates," Amanda E. Hargrove, Jevgenij A. Raskatov, Jordan L. Meier, David C. Montgomery, Peter B Dervan.

J. Med. Chem., 55, 5425–5432, (2012).

334 "Microwave Assisted Synthesis of Py-Im Polyamides," James W. Puckett, Joshua T. Green, Peter B. Dervan.

Org. Lett, 14, 2774-2777, (2012).

333 "Pharmacokinetics of Py-Im Polyamides Depend on Architecture: Cyclic versus Linear," Jevgenij A. Raskatov, Amanda E. Hargrove, Alex Y. So, Peter B. Dervan.

J. Am. Chem. Soc., 134, 7995–7999, (2012).

332 "Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells," Christine Jespersen, Elisabetta Soragni, C. James Chou, Paramjit S. Arora, Peter B. Dervan, Joel M. Gottesfeld.

Bioorg. Med. Chem. Lett., 22, 4068–4071, (2012).

331 "Modulation of NF-kappaB-dependent gene transcription using programmable DNA minor groove binders," Jevgenij A. Raskatov, Jordan L. Meier, James W. Puckett, Fei Yang, Parameswaran Ramakrishnan, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 109, 1023–1028, (2012).

330 "Enhancing the Cellular Uptake of Py-Im Polyamides through Next-Generation Aryl Turns," Jordan L. Meier, David C. Montgomery, Peter B. Dervan.

Nucleic Acids Res, 40, 2345-2356, (2012).

329 "Targeting a DNA Binding Motif of the EVI1 Protein by a Pyrrole-Imidazole Polyamide," Yi Zhang, Géraldine Sicot, Xiaohui Cui, Marion Vogel, Charles A. Wuertzer, Kimberly A. Lezon-Geyda, John C. Wheeler, Daniel A. Harki, Katy A. Muzikar, Daniel A. Stolper, Peter B. Dervan, Archibald S. Perkins.

Biochemistry, 50, 10431–10441, (2011).

328 "Expanding the Repertoire of Natural Product-Inspired Ring Pairs for Molecular Recognition of DNA," Katy A. Muzikar, Jordan L. Meier, Daniel A. Gubler, Jevgenij A. Raskatov, Peter B. Dervan.

Org. Lett, 13, 5612-5615, (2011).

327 "Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding," David M. Chenoweth, Peter B. Dervan.

J. Am. Chem. Soc., 132, 14521–14529, (2010).

326 "Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression," Katy A. Muzikar, Nicholas G. Nickols, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 106, 16598-16603, (2009).

325 " Oligomerization Route to Py-Im Polyamide Macrocycles," David M. Chenoweth, Daniel A. Harki, Peter B. Dervan.

Org. Lett., 11, 3590–3593, (2009).

324 "Allosteric modulation of DNA by small molecules," David M. Chenoweth, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 106, 13175-13179, (2009).

323 "Modifications at the C-Terminus To Improve Pyrrole-Imidazole Polyamide Activity in Cell Culture," Claire S. Jacobs, Peter B. Dervan.

J. Med. Chem., 52, 7380–7388, (2009).

322 "Quantitative detection of small molecule/DNA complexes employing a force-based and label-free DNA-microarray," Dominik Ho, Christian Dose, Christian H. Albrecht, Philip Severin, Katja Falter, Peter B. Dervan, Hermann E. Gaub.

Biophys. J., 96, 4661–4671, (2009).

321 "Cyclic pyrrole-imidazole polyamides targeted to the androgen response element," David M. Chenoweth, Daniel A. Harki, John W. Phillips, Christian Dose, Peter B. Dervan.

J. Am. Chem. Soc., 131, 7182–7188, (2009).

320 "Solution-phase synthesis of pyrrole-imidazole polyamides," David M. Chenoweth, Daniel A. Harki, Peter B. Dervan.

J. Am. Chem. Soc., 131, 7175–7181, (2009).

319 "DNA sequence selectivity of hairpin polyamide turn units," Michelle E. Farkas, Benjamin C. Li, Christian Dose, Peter B. Dervan.

Bioorg. Med. Chem. Lett., 19, 3919-3923, (2009).

318 "Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells.," Carey F. Hsu, Peter B. Dervan.

Bioorg. Med. Chem. Lett., 18, 5851-5855, (2008).

317 "In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography," Daniel A. Harki, Nagichettiar Satyamurthy, David B. Stout, Michael E. Phelps, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 105, 13039-13044, (2008).

316 "Next Generation Hairpin Polyamides with (R)-3,4-Diaminobutyric Acid Turn Unit," Christian Dose, Michelle E. Farkas, David M. Chenoweth, Peter B. Dervan.

J. Am. Chem. Soc., 130, 6859-6866, (2008).

315 "Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia," C. James Chou, Michelle E. Farkas, Sherry M. Tsai, David Alvarez, Peter B. Dervan, Joel M. Gottesfeld.

Mol. Cancer Ther., 7, 769-778, (2008).

314 "Targeted chemical wedges reveal the role of allosteric DNA modulation in protein - DNA assembly," Rocco Moretti, Leslie J. Donato, Mary L. Brezinski, Ryan L. Stafford, Helena Hoff, Jon S. Thorson, Peter B. Dervan, Aseem Z. Ansari.

ACS Chem. Biol., 3, 220-229, (2008).

313 "Programming Multiple Protein Patterns on a Single DNA Nanostructure," Justin D. Cohen, John P. Sadowski, Peter B. Dervan.

J. Am. Chem. Soc., 130, 402-403, (2008).

312 "The Reach of Linear Protein-DNA Dimerizers," Ryan L. Stafford, Peter B. Dervan.

J. Am. Chem. Soc., 129, 14026-14033, (2007).

311 "Quantitative Microarray Profiling of DNA Binding Molecules," James W. Puckett, Katy A. Muzikar, Josh Tietjen, Christopher L. Warren, Aseem Z. Ansari, Peter B. Dervan.

J. Am. Chem. Soc., 129, 12310-12319, (2007).

310 "Recognition of "Mirror-Image" DNA by Small Molecules," Christian Dose, Dominik Ho, Hermann E. Gaub, Peter B. Dervan, Christian H. Albrecht.

Angew. Chem. Int. Ed., 46, 8384-8387, (2007).

309 "Addressing Single Molecules on DNA Nanostructures," Justin D. Cohen, John P. Sadowski, Peter B. Dervan.

Angew. Chem. Int. Ed., 46, 7956-7959, (2007).

308 "α-Diaminobutyric acid-linked hairpin polyamides," Michelle E. Farkas, Sherry M. Tsai, Peter B. Dervan.

Bioorg. Med. Chem., 15, 6927-6936, (2007).

307 "Modulating Hypoxia-Inducible Transcription by Disrupting the HIF-1–DNA Interface," Nicholas G. Nickols, Claire S. Jacobs, Michelle E. Farkas, Peter B. Dervan.

ACS Chem. Biol., 2, 561-571, (2007).

306 "Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide," Nicholas G. Nickols, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 104, 10418-10423, (2007).

305 "Completion of a Programmable DNA-Binding Small Molecule Library," Carey F. Hsu, John W. Phillips, John W. Trauger, Michelle E. Farkas, Jason M. Belitsky, Alexander Heckel, Bogdan Z. Olenyuk, James W. Puckett, Clay C. C. Wang, Peter B. Dervan.

Tetrahedron, 63, 6146-6151, (2007).

304 "Minimization of a Protein-DNA Dimerizer," Ryan L. Stafford, Hans-Dieter Arndt, Mary L. Brezinski, Aseem Z. Ansari, Peter B. Dervan.

J. Am. Chem. Soc., 129, 2660-2668, (2007).

303 "Fluorescent Sequence-Specific dsDNA Binding Oligomers," David M. Chenoweth, Anne Viger, Peter B. Dervan.

J. Am. Chem. Soc., 129, 2216-2217, (2007).

302 "Improved Nuclear Localization of DNA-binding polyamides," Nicholas G. Nickols, Claire S. Jacobs, Michelle E. Farkas, Peter B. Dervan.

Nucleic Acids Res., 35, 363-370, (2007).

301 "Unanticipated Differences in the Comparison of α- versus γ-Diaminobutyric Acid-linked Hairpin Polyamide-Alkylator Conjugates," Sherry M. Tsai, Michelle E. Farkas, C. J. Chou, Joel M. Gottesfeld, Peter B. Dervan.

Nucleic Acids Res., 35, 307-316, (2007).

300 "Programmable oligomers targeting 5'-GGGG-3' in the minor groove of DNA and NF-κB binding inhibition," David M. Chenoweth, Julie A. Poposki, Michael A. Marques, Peter B. Dervan.

Bioorg. Med. Chem., 15, 759-770, (2007).

299 "Exploring the limits of benzimidazole DNA-binding oligomers for the hypoxia inducible factor (HIF) site," Anne Viger, Peter B. Dervan.

Bioorg. Med. Chem., 14, 8539-8549, (2006).

298 "DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA·TTC repeats in Friedreich's ataxia," Ryan Burnett, Christian Melander, James W. Puckett, Leslie S. Son, Robert D. Wells, Peter B. Dervan, Joel M. Gottesfeld.

Proc. Natl. Acad. Sci. USA, 103, 11497-11502, (2006).

297 "A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate," D. Alvarez, C. J. Chou, L. Latella, S. G. Zeitlin, S. Ku, P. L. Puri, Peter B. Dervan, Joel M. Gottesfeld.

Cell Cycle, 5, 1537-1548, (2006).

296 "Programmable Oligomers for Minor Groove DNA Recognition," Raymond M. Doss, Michael A. Marques, Shane Foister, David M. Chenoweth, Peter B. Dervan.

J. Am. Chem. Soc., 128, 9074-9079, (2006).

295 "Defining the sequence-recognition profile of DNA-binding molecules," Christopher L. Warren, Natasha C. S. Kartochvil, Karl E. Hauschild, Shane Foister, Mary L. Brezinski, Peter B. Dervan, George N. Phillips, Jr., Aseem Z. Ansari.

Proc. Natl. Acad. Sci. USA, 103, 867-872, (2006).

294 "Sequence-Specific Fluorescence Detection of DNA by Polyamide-Thiazole Orange Conjugates," Eric J. Fechter, Bogdan Olenyuk, Peter B. Dervan.

J. Am. Chem. Soc., 127, 16685-16691, (2005).

293 "Inhibition of DNA Binding by Human Estrogen-Related Receptor 2 and Estrogen Receptor α with Minor Groove Binding Polyamides," Micah D. Gerhart, Liliane Dickinson, Jennifer Ehley, Christian Melander, Peter B. Dervan, Peter E. Wright, Joel M. Gottesfeld.

Biochemistry, 44, 4196-4203, (2005).

292 "Regulation of Gene Expression by Synthetic DNA-Binding Ligands," Peter B. Dervan, Adam T. Poulin-Kerstien, Eric J. Fechter, Benjamin S. Edelson.

Top. Curr. Chem., 253, 1-31, (2005).

291 "Temperature-sensitive protein-DNA dimerizers," Karl E. Hauschild, Renee E. Metzler, Hans-Dieter Arndt, Rocco Moretti, Marni Raffaelle, Peter B. Dervan, Aseem Z. Ansari.

Proc. Natl. Acad. Sci. USA, 102, 5008-5013, (2005).

290 "DNA Damage Effects of a Polyamide-CBI Conjugate in SV40 Virions," Brian J. Philips, Aileen Y. Chang, Peter B. Dervan, Terry A. Beerman.

Mol. Pharmacol., 67, 877-882, (2005).

289 "Nucleosomes in Solution Exist as a Mixture of Twist-defect States," Rajeswari S. Edayathumangalam, Philipp Weyermann, Peter B. Dervan, Joel M. Gottesfeld, Karolin Luger.

J. Mol. Biol., 345, 103-114, (2005).

288 "Programmable DNA binding oligomers for control of transcription," Peter B. Dervan, Raymond M. Doss, Michael A. Marques.

Curr. Med. Chem.: Anti-Cancer Agents, 5, 373-387, (2005).

287 "Small Molecule Transcription Factor Mimic," Youngjoo Kwon, Hans-Dieter Arndt, Qian Mao, Yongmun Choi, Yoshinori Kawazoe, Peter B. Dervan, Motonari Uesugi.

J. Am. Chem. Soc., 126, 15940-15941, (2004).

286 "Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist," Bogdan Z. Olenyuk, Guo-Jun Zhang, Jeffrey M. Klco, Nicholas G. Nickols, William G. Kaelin, Jr., Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 101, 16768-16773, (2004).

285 "Arresting Cancer Proliferation by Small-Molecule Gene Regulation," Liliane A. Dickinson, Ryan Burnett, Christian Melander, Benjamin S. Edelson, Paramjit S. Arora, Peter B. Dervan, Joel M. Gottesfeld.

Chem. Biol., 11, 1583-1594, (2004).

284 "Paradoxical Effects of DNA Binding Polyamides on HTLV-1 Transcription," Jill A. Livengood, Eric J. Fechter, Peter B. Dervan, Jennifer K. Nyborg.

Front. Biosci., 9, 3058-3067, (2004).

283 "Expanding the Repertoire of Heterocycle Ring Pairs for Programmable Minor Groove DNA Recognition," Michael A. Marques, Raymond M. Doss, Shane Foister, Peter B. Dervan.

J. Am. Chem. Soc., 126, 10339-10349, (2004).

282 "NMR Structure of a Cyclic Polyamide-DNA Complex," Qing Zhang, Tammy J. Dwyer, Vickie Tsui, David A. Case, Junhyeong Cho, Peter B. Dervan, David E. Wemmer.

J. Am. Chem. Soc., 126, 7958-7966, (2004).

281 "Influence of structural variation on nuclear localization of DNA-binding polyamide-fluorophore conjugates," Benjamin S. Edelson, Timothy P. Best, Bogdan Olenyuk, Nicholas G. Nickols, Raymond M. Doss, Shane Foister, Alexander Heckel, Peter B. Dervan.

Nucleic Acids Res., 32, 2802-2818, (2004).

280 "Design of a Sequence-Specific DNA Bisintercalator," Eric J. Fechter, Bogdan Olenyuk, Peter B. Dervan.

Angew. Chem. Int. Ed., 43, 3591-3594, (2004).

279 "Polyamides Reveal a Role for Repression in Latency within Resting T Cells of HIV-Infected Donors," Loyda Ylisastigui, Jason J. Coull, Victor C. Rucker, Christian Melander, Ronald J. Bosch, Scott J. Brodie, Lawrence Corey, Donald L. Sodora, Peter B. Dervan, David M. Margolis.

J. Infect. Dis., 190, 1429-1437, (2004).

278 "DNA Minor-Groove Recognition by 3-Methylthiophene/Pyrrole Pair," Raymond M. Doss, Michael A. Marques, Shane Foister, Peter B. Dervan.

Chem. Biodiversity, 1, 886-899, (2004).

277 "Mechanism of Sequence-Specific Fluorescent Detection of DNA by N-Methyl-imidazole, N-Methyl-pyrrole, and β-Alanine Linked Polyamides," Victor C. Rucker, Alexander R. Dunn, Shantanu Sharma, Peter B. Dervan, Harry B. Gray.

J. Phys. Chem. B, 108, 7490-7494, (2004).

276 "Molecular recognition of the nucleosomal "supergroove"," Rajeswari S. Edayathumangalam, Philipp Weyermann, Joel M. Gottesfeld, Peter B. Dervan, Karolin Luger.

Proc. Natl. Acad. Sci. USA, 101, 6864-6869, (2004).

275 "Allosteric Inhibition of Zinc-Finger Binding in the Major Groove of DNA by Minor-Groove Binding Ligands," Doan H. Nguyen-Hackley, Elizabeth Ramm, Christina M. Taylor, J. Keith Joung, Peter B. Dervan, Carl O. Pabo.

Biochemistry, 43, 3880-3890, (2004).

274 "Regulation of Gene Expression with Pyrrole-Imidazole Polyamides," Peter B. Dervan, Eric J. Fechter, Ben S. Edelson, Joel M. Gottesfeld.

Pseudo-peptides in Drug Discovery (P. E. Nielsen (Ed.)), 121-152, Wiley-VCH, (2004).

273 "DNA-Templated Dimerization of Hairpin Polyamides," Adam T. Poulin-Kerstien, Peter B. Dervan.

J. Am. Chem. Soc., 125, 15811-15821, (2003).

272 "Toward Artificial Developmental Regulators," Hans-Dieter Arndt, Karl E. Hauschild, David P. Sullivan, Kara Lake, Peter B. Dervan, Aseem Z. Ansari.

J. Am. Chem. Soc., 125, 13322-13323, (2003).

271 "Nuclear localization of pyrrole-imidazole polyamide-fluorescein conjugates in cell culture," Timothy P. Best, Benjamin S. Edelson, Nicholas G. Nickols, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 100, 12063-12068, (2003).

270 "Accessibility of Nuclear Chromatin by DNA Binding Polyamides," Brigitte A. Dudouet, Ryan Burnett, Liliane A. Dickinson, Malcolm R. Wood, Christian Melander, Jason M. Belitsky, Benjamin Edelson, Nicholas Wurtz, Christoph Briehn, Peter B. Dervan, Joel M. Gottesfeld.

Chem. Biol., 10, 859-867, (2003).

269 "Influence of β-Alanine on Hairpin Polyamide Orientation in the DNA Minor Groove," Victor C. Rucker, Christian Melander, Peter B. Dervan.

Helv. Chim. Acta, 87, 1839-1851, (2003).

268 "Shape Selective Recognition of T·A Base Pairs by Hairpin Polyamides Containing N-Terminal 3-Methoxy (and 3-Chloro) Thiophene Residues," Shane Foister, Michael A. Marques, Raymond M. Doss, Peter B. Dervan.

Bioorg. Med. Chem., 11, 4333-4340, (2003).

267 "Recognition of the DNA minor groove by pyrrole-imidazole polyamides," Peter B. Dervan, Benjamin S. Edelson.

Curr. Opin. Struc. Biol., 13, 284-299, (2003).

266 "U-Pin Polyamide Motif for Recognition of the DNA Minor Groove," Alexander Heckel, Peter B. Dervan.

Chem. Eur. J., 9, 3353-3366, (2003).

265 "Allosteric Inhibition of Protein-DNA Complexes by Polyamide-Intercalator Conjugates," Eric J. Fechter, Peter B. Dervan.

J. Am. Chem. Soc., 125, 8476-8485, (2003).

264 "Inhibition of Moloney Murine Leukemia Virus Integration Using Polyamides Targeting the Long-Terminal Repeat Sequences," Fan Yang, Jason M. Belitsky, Rodrigo A. Villanueva, Peter B. Dervan, Monica J. Roth.

Biochemistry, 42, 6249-6258, (2003).

263 "Imidazopyridine/Pyrrole and Hydroxybenzimidazole/Pyrrole Pairs for DNA Minor Groove Recognition," Dorte Renneberg, Peter B. Dervan.

J. Am. Chem. Soc., 125, 5707-5716, (2003).

262 "Alternative Heterocycles for DNA Recognition: The Benzimidazole/Imidazole Pair," Christoph A. Briehn, Philipp Weyermann, Peter B. Dervan.

Chem. Eur. J., 9, 2110-2122, (2003).

261 "Parallel Synthesis of H-pin Polyamides by Alkene Metathesis on Solid Phase," Bogdan Olenyuk, Cristian Jitianu, Peter B. Dervan.

J. Am. Chem. Soc., 125, 4741-4751, (2003).

260 "Crystal Structures of Nucleosome Core Particles in Complex with Minor Groove DNA-binding Ligands," Robert K. Suto, Rajeswari S. Edayathumangalam, Cindy L. White, Christian Melander, Joel M. Gottesfeld, Peter B. Dervan, Karolin Luger.

J. Mol. Biol., 326, 371-380, (2003).

259 "DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate," Yong-Dong Wang, Jaroslaw Dziegielewski, Nicholas R. Wurtz, Barbara Dziegielewska, Peter B. Dervan, Terry A. Beerman.

Nucleic Acids Res., 31, 1208-1215, (2003).

258 "Sequence Specific Fluorescence Detection of Double Strand DNA," Victor C. Rucker, Shane Foister, Christian Melander, Peter B. Dervan.

J. Am. Chem. Soc., 125, 1195-1202, (2003).

257 "Analysis of Hairpin Polyamide Complexes Having DNA Binding Sites in Close Proximity," Cheryl A. Hawkins, Eldon E. Baird, Peter B. Dervan, David E. Wemmer.

J. Am. Chem. Soc., 124, 12689-12696, (2002).

256 "Cell-free and Cellular Activities of a DNA Sequence Selective Hairpin Polyamide-CBI Conjugate," Yong-Dong Wang, Jaroslaw Dziegielewski, Aileen Y. Chang, Peter B. Dervan, Terry A. Beerman.

J. Biol. Chem., 277, 42431-42437, (2002).

255 "Toward an Understanding of the Chemical Etiology for DNA Minor-Groove Recognition by Polyamides," Michael A. Marques, Raymond M. Doss, Adam R. Urbach, Peter B. Dervan.

Helv. Chim. Acta, 85, 4485-4517, (2002).

254 "Targeted Derepression of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Pyrrole-Imidazole Polyamides," Jason J. Coull, Guocheng He, Christian Melander, Victor C. Rucker, Peter B. Dervan, David M. Margolis.

J. Virol., 76, 12349-12354, (2002).

253 "Design of Artificial Transcriptional Activators with Rigid Poly-L-proline Linkers," Paramjit S. Arora, Aseem Z. Ansari, Timothy P. Best, Mark Ptashne, Peter B. Dervan.

J. Am. Chem. Soc., 124, 13067-13071, (2002).

252 "Blocking Transcription Through a Nucleosome with Synthetic DNA Ligands," Joel M. Gottesfeld, Jason M. Belitsky, Christian Melander, Peter B. Dervan, Karolin Luger.

J. Mol. Biol., 321, 249-263, (2002).

251 "Search for the Optimal Linker in Tandem Hairpin Polyamides," Inger Kers, Peter B. Dervan.

Bioorg. Med. Chem., 10, 3339-3349, (2002).

250 "Cellular Uptake of N-Methylpyrrole/N-Methylimidazole Polyamide-Dye Conjugates," Jason M. Belitsky, Stephanie J. Leslie, Paramjit S. Arora, Terry A. Beerman, Peter B. Dervan.

Bioorg. Med. Chem., 10, 3313-3318, (2002).

249 "Structure of a β-Alanine-linked Polyamide Bound to a Full Helical Turn of Purine Tract DNA in the 1:1 Motif," Adam R. Urbach, John J. Love, Scott A. Ross, Peter B. Dervan.

J. Mol. Biol., 320, 55-71, (2002).

248 "Recognition of Ten Base Pairs of DNA by Head-to-Head Hairpin Dimers," Philipp Weyermann, Peter B. Dervan.

J. Am. Chem. Soc., 124, 6872-6876, (2002).

247 "Solid-Phase Synthesis of DNA Binding Polyamides on Oxime Resin," Jason M. Belitsky, Doan H. Nguyen, Nicholas R. Wurtz, Peter B. Dervan.

Bioorg. Med. Chem., 10, 2767-2774, (2002).

246 "Inhibition of DNA Binding by NF-κB with Pyrrole-Imidazole Polyamides," Nicholas R. Wurtz, Joel L. Pomerantz, David Baltimore, Peter B. Dervan.

Biochemistry, 41, 7604-7609, (2002).

245 "Promoter Scanning for Transcription Inhibition with DNA-Binding Polyamides," Jennifer A. Ehley, Christian Melander, David Herman, Eldon E. Baird, Heather A. Ferguson, James A. Goodrich, Peter B. Dervan, Joel M. Gottesfeld.

Mol. Cell. Biol., 22, 1723-1733, (2002).

243 "Molecular Recognition of DNA by Small Molecules," Peter B. Dervan.

Bioorg. Med. Chem., 9, 2215-2235, (2001).

242 "Sequence-Specific Trapping of Topoisomerase I by DNA Binding Polyamide-Camptothecin Conjugates," Clay C. C. Wang, Peter B. Dervan.

J. Am. Chem. Soc., 123, 8657-8661, (2001).

241 "Inhibition of Major Groove DNA Binding bZIP Proteins by Positive Patch Polyamides," Ryan E. Bremer, Nicholas R. Wurtz, Jason W. Szewczyk, Peter B. Dervan.

Bioorg. Med. Chem., 9, 2093-2103, (2001).

240 "Towards a minimal motif for artificial transcriptional activators," Aseem Z. Ansari, Anna K. Mapp, Doan H. Nguyen, Peter B. Dervan, Mark Ptashne.

Chem. Biol., 8, 583-592, (2001).

239 "Footprinting Methods for Analysis of Pyrrole-Imidazole/DNA Complexes," John W. Trauger, Peter B. Dervan.

Methods Enzymol., 340, 450-466, (2001).

238 "Sequence-specific Recognition of DNA in the Nucleosome by Pyrrole-Imidazole Polyamides," Joel M. Gottesfeld, Christian Melander, Robert K. Suto, Holger Raviol, Karolin Luger, Peter B. Dervan.

J. Mol. Biol., 309, 615-629, (2001).

237 "Fmoc Solid Phase Synthesis of Polyamides Containing Pyrrole and Imidazole Amino Acids," Nicholas R. Wurtz, James M. Turner, Eldon E. Baird, Peter B. Dervan.

Org. Lett., 3, 1201-1203, (2001).

236 "Toward rules for 1:1 polyamide:DNA recognition," Adam R. Urbach, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 98, 4343-4348, (2001).

235 "Expanding the Recognition of the Minor Groove of DNA by Incorporation of β-Alanine in Hairpin Polyamides," Clay C. C. Wang, Ulf Ellervik, Peter B. Dervan.

Bioorg. Med. Chem., 9, 653-657, (2001).

234 "Alternative Heterocycles for DNA Recognition: An N-Methylpyrazole/N-Methylpyrrole Pair Specifies for A·T/T·A Base Pairs," Doan H. Nguyen, Jason W. Szewczyk, Eldon E. Baird, Peter B. Dervan.

Bioorg. Med. Chem., 9, 7-17, (2001).

233 "Kinetic Consequences of Covalent Linkage of DNA Binding Polyamides," Ramesh Baliga, Eldon E. Baird, David M. Herman, Christian Melander, Peter B. Dervan, Donald M. Crothers.

Biochemistry, 40, 3-8, (2001).

232 "Preparation of thioesters for the ligation of peptides with non-native substrates," Anna K. Mapp, Peter B. Dervan.

Tetrahedron Lett., 41, 9451-9454, (2000).

231 "Discrimination of A/T Sequences in the Minor Groove of DNA within a Cyclic Polyamide Motif," Christian Melander, David M. Herman, Peter B. Dervan.

Chem. Eur. J., 6, 4487-4497, (2000).

230 "Hydroxybenzamide/Pyrrole Pair Distinguishes T·A from A·T Base Pairs in the Minor Groove of DNA," Ulf Ellervik, Clay C. C. Wang, Peter B. Dervan.

J. Am. Chem. Soc., 122, 9354-9360, (2000).

229 "Chemical Approaches to Control Gene Expression," Joel M. Gottesfeld, James M. Turner, Peter B. Dervan.

Gene Expression, 9, 77-92, (2000).

228 "Alternative Heterocycles for DNA Recognition: A 3-Pyrazole/Pyrrole Pair Specifies for G·C Base Pairs," Zheng-Yun J. Zhan, Peter B. Dervan.

Bioorg. Med. Chem., 8, 2467-2474, (2000).

227 "Molecular Recognition of DNA by Hoechst Benzimidazoles: Exploring Beyond the Pyrrole-Imidazole-Hydroxypyrrole Polyamide-Pairing Code," Thomas G. Minehan, Konstanze Gottwald, Peter B. Dervan.

Helv. Chim. Acta, 83, 2197-2213, (2000).

226 "Asymmetric DNA Binding by A Homodimeric bHLH Protein," Rachel L. Winston, Jennifer A. Ehley, Eldon E. Baird, Peter B. Dervan, Joel M. Gottesfeld.

Biochemistry, 39, 9092-9098, (2000).

225 "Recognition of the Minor Groove of DNA by Hairpin Polyamides Containing α-Substituted-β-Amino Acids," Paul E. Floreancig, Susanne E. Swalley, John W. Trauger, Peter B. Dervan.

J. Am. Chem. Soc., 122, 6342-6350, (2000).

224 "Recognition of the DNA Minor Groove by Pyrrole-Imidazole Polyamides: Comparison of Desmethyl- and N-Methylpyrrole," Ryan E. Bremer, Jason W. Szewczyk, Eldon E. Baird, Peter B. Dervan.

Bioorg. Med. Chem., 8, 1947-1955, (2000).

223 "Targeting the Ets Binding Site of the HER2/neu Promoter with Pyrrole-Imidazole Polyamides," Shu-Yuan Chiang, Roland W. Bürli, Chris C. Benz, Loretta Gawron, Gary K. Scott, Peter B. Dervan, Terry A. Beerman.

J. Biol. Chem., 275, 24246-24254, (2000).

222 "Controlling Binding Orientation in Hairpin Polyamide DNA Complexes," Cheryl A. Hawkins, Rafael Peláez de Clairac, Raymond N. Dominey, Eldon E. Baird, Sarah White, Peter B. Dervan, David E. Wemmer.

J. Am. Chem. Soc., 122, 5235-5243, (2000).

221 "Strand Selective Cleavage of DNA by Diastereomers of Hairpin Polyamide-seco-CBI Conjugates," Aileen Y. Chang, Peter B. Dervan.

J. Am. Chem. Soc., 122, 4856-4864, (2000).

220 "Selective inhibition of DNA gyrase in vitro by a GC specific eight-ring hairpin polyamide at nanomolar concentration," H. Simon, L. Kittler, Eldon E. Baird, Peter B. Dervan, C. Zimmer.

FEBS Lett., 471, 173-176, (2000).

219 "Activation of gene expression by small molecule transcription factors," Anna K. Mapp, Aseem Z. Ansari, Mark Ptashne, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 97, 3930-3935, (2000).

218 "Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates," Nicholas R. Wurtz, Peter B. Dervan.

Chem. Biol., 7, 153-161, (2000).

217 "Structural Effects of DNA Sequence on T·A Recognition by Hydroxypyrrole/Pyrrole Pairs in the Minor Groove," Clara L. Kielkopf, Ryan E. Bremer, Sarah White, Jason W. Szewczyk, James M. Turner, Eldon E. Baird, Peter B. Dervan, Douglas C. Rees.

J. Mol. Biol., 295, 557-567, (2000).

216 "Sequence Selectivity of 3-Hydroxypyrrole/Pyrrole Ring Pairings in the DNA Minor Groove," Adam R. Urbach, Jason W. Szewczyk, Sarah White, James M. Turner, Eldon E. Baird, Peter B. Dervan.

J. Am. Chem. Soc., 121, 11621-11629, (1999).

215 "Sequence-specific DNA recognition by polyamides," Peter B. Dervan, Roland W. Bürli.

Curr. Opin. Chem. Biol., 38, 688-693, (1999).

214 "The Tax Protein-DNA Interaction is Essential for HTLV-I Transactivation in Vitro," Brian A. Lenzmeier, Eldon E. Baird, Peter B. Dervan, Jennifer K. Nyborg.

J. Mol. Biol., 291, 731-744, (1999).

213 "Anti-represion of RNA Polymerase II Transcription by Pyrrole-Imidazole Polyamides," Liliane A. Dickinson, John W. Trauger, Eldon E. Baird, Peter Ghazal, Peter B. Dervan, Joel M. Gottesfeld.

Biochemistry, 38, 10801-10807, (1999).

212 "Inhibition of Ets-1 DNA Binding and Ternary Complex Formation between Ets-1, NF-κB, and DNA by a Designed DNA-binding Ligand," Liliane A. Dickinson, John W. Trauger, Eldon E. Baird, Peter B. Dervan, Barbara J. Graves, Joel M. Gottesfeld.

J. Biol. Chem., 274, 12765-12773, (1999).

211 "Minor Groove DNA-Protein Contacts Upstream of a tRNA Gene Detected with a Synthetic DNA Binding Ligand," Steven J. McBryant, Eldon E. Baird, John W. Trauger, Peter B. Dervan, Joel M. Gottesfeld.

J. Mol. Biol., 286, 973-981, (1999).

210 "NMR Characterization of the Aliphatic β/β Pairing for Recognition of A·T/T·A Base Pairs in the Minor Groove of DNA," Rafael Peláez Lamamie de Clairac, Christian J. Seel, Bernhard H. Geierstanger, Milan Mrksich, Eldon E. Baird, Peter B. Dervan, David E. Wemmer.

J. Am. Chem. Soc., 121, 2956-2964, (1999).

209 "The Thermodynamics of Polyamide-DNA Recognition: Hairpin Polyamide Binding in the Minor Groove of Duplex DNA," Daniel S. Pilch, Nataša Poklar, Eldon E. Baird, Peter B. Dervan, Kenneth J. Breslauer.

Biochemistry, 38, 2143-2151, (1999).

208 "Tandem Hairpin Motif for Recognition in the Minor Groove of DNA by Pyrrole-Imidazole Polyamides," David M. Herman, Eldon E. Baird, Peter B. Dervan.

Chem. Eur. J., 5, 975-983, (1999).

207 "Cycle Polyamide Motif for Recognition of the Minor Groove of DNA," David M. Herman, James M. Turner, Eldon E. Baird, Peter B. Dervan.

J. Am. Chem. Soc., 121, 1121-1129, (1999).

206 "Effects of γ-Turn and β-Tail Amino Acids on Sequence-Specific Recognition of DNA by Hairpin Polyamides," Susanne E. Swalley, Eldon E. Baird, Peter B. Dervan.

J. Am. Chem. Soc., 121, 1113-1120, (1999).

205 "Affinity and Specificity of Multiple Hydroxypyrrole/Pyrrole Ring Pairings for Coded Recognition of DNA," Sarah White, James M. Turner, Jason W. Szewczyk, Eldon E. Baird, Peter B. Dervan.

J. Am. Chem. Soc., 121, 260-261, (1999).

204 "Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands," Liliane A. Dickinson, Richard J. Gulizia, John W. Trauger, Eldon E. Baird, Donald E. Mosier, Joel M. Gottesfeld, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 95, 12890-12895, (1998).

203 "A Structural Basis for Recognition of A·T and T·A Base Pairs in the Minor Groove of B-DNA," Clara L. Kielkopf, Sarah White, Jason W. Szewczyk, James M. Turner, Eldon E. Baird, Peter B. Dervan, Douglas C. Rees.

Science, 282, 111-115, (1998).

202 "Aliphatic/Aromatic Amino Acid Pairings for Polyamide Recognition in the Minor Groove of DNA," James M. Turner, Susanne E. Swalley, Eldon E. Baird, Peter B. Dervan.

J. Am. Chem. Soc., 120, 6219-6226, (1998).

201 "Cooperative Hairpin Dimers for Recognition of DNA by Pyrrole-Imidazole Polyamides," John W. Trauger, Eldon E. Baird, Peter B. Dervan.

Angew. Chem. Int. Ed., 37, 1421-1423, (1998).

200 "Recognition of 16 Base Pairs in the Minor Groove of DNA by a Pyrrole-Imidazole Polyamide Dimer," John W. Trauger, Eldon E. Baird, Peter B. Dervan.

J. Am. Chem. Soc., 120, 3534-3535, (1998).

199 "Structure of a stereoregular phosphorothioate DNA/RNA duplex," M. Bachelin, G. Hessler, G. Kurz, J. G. Hacia, P. B. Dervan, H. Kessler.

Nat. Struct. Biol., 5, 271-276, (1998).

198 "Inhibition of major-groove-binding-proteins by pyrrole-imidazole polyamides with an Arg-Pro-Arg positive patch," Ryan E. Bremer, Eldon E. Baird, Peter B. Dervan.

Chem. Biol., 5, 119-133, (1998).

197 "A Comparison of H-Pin and Hairpin Polyamide Motifs for the Recognition of the Minor Groove of DNA," William A. Greenberg, Eldon E. Baird, Peter B. Dervan.

Chem. Eur. J., 4, 796-805, (1998).

196 "Structural basis for G·C recognition in the DNA minor groove," Clara L. Kielkopf, Eldon E. Baird, Peter B. Dervan, Douglas C. Rees.

Nat. Struct. Biol., 5, 104-109, (1998).

195 "Stereochemical Control of the DNA Binding Affinity, Sequence Specificity, and Orientation Preference of Chiral Hairpin Polyamides in the Minor Groove," David M. Herman, Eldon E. Baird, Peter B. Dervan.

J. Am. Chem. Soc., 120, 1382-1391, (1998).

194 "Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands," Sarah White, Jason W. Szewczyk, James M. Turner, Eldon E. Baird, Peter B. Dervan.

Nature, 391, 468-471, (1998).

193 "Importance of Minor Groove Binding Zinc Fingers within the Transcription Factor IIIA-DNA Complex," Laura Neely, John W. Trauger, Eldon E. Baird, Peter B. Dervan, Joel M. Gottesfeld.

J. Mol. Biol., 274, 439-445, (1997).

192 "136. Triple-Helix Formation by Pyrimidine Oligonucleotides Containing Nonnatural Nucleosides with Extended Aromatic Nucleobases: Intercalation from the Major Groove as a Method for Recognizing C&mid," Thomas E. Lehmann, William A. Greenberg, David A. Liberles, Carol K. Wada, Peter B. Dervan.

Helv. Chim. Acta, 80, 2002-2022, (1997).

191 "On the pairing rules for recognition in the minor groove of DNA by pyrrole-imidazole polyamides," Sarah White, Eldon E. Baird, Peter B. Dervan.

Chem. Biol., 4, 569-576, (1997).

190 "Orientation Preferences of Pyrrole-Imidazole Polyamides in the Minor Groove of DNA," Sarah White, Eldon E. Baird, Peter B. Dervan.

J. Am. Chem. Soc., 119, 8756-8765, (1997).

189 "A Pyrrole-Imidazole Polyamide Motif for Recognition of Eleven Base Pair Sequences in the Minor Groove of DNA," Susanne E. Swalley, Eldon E. Baird, Peter B. Dervan.

Chem. Eur. J., 3, 1600-1607, (1997).

188 "Recognition of Seven Base Pair Sequences in the Minor Groove of DNA by Ten-Ring Pyrrole-Imidazole Polyamide Hairpins," James M. Turner, Eldon E. Baird, Peter B. Dervan.

J. Am. Chem. Soc., 119, 7636-7644, (1997).

187 "Discrimination of 5'-GGGG-3', 5'-GCGC-3', and 5'-GGCC-3' Sequences in the Minor Groove of DNA by Eight-Ring Hairpin Polyamides," Susanne E. Swalley, Eldon E. Baird, Peter B. Dervan.

J. Am. Chem. Soc., 119, 6953-6961, (1997).

186 "Targeting the minor groove of DNA," David E. Wemmer, Peter B. Dervan.

Curr. Opin. Struc. Biol., 7, 355-361, (1997).

185 "NMR Characterization of Hairpin Polyamide Complexes with the Minor Groove of DNA," Rafael Peláez Lamamie de Clairac, Bernhard H. Geierstanger, Milan Mrksich, Peter B. Dervan, David E. Wemmer.

J. Am. Chem. Soc., 119, 7909-7916, (1997).

184 "Regulation of gene expression by small molecules," Joel M. Gottesfeld, Laura Neely, John W. Trauger, Eldon E. Baird, Peter B. Dervan.

Nature, 387, 202-205, (1997).

183 "Kinetic Analysis of Sequence-Specific Alkylation of DNA by Pyrimidine Oligodeoxyribonucleotide-Directed Triple-Helix Formation," Matthew J. Taylor, Peter B. Dervan.

Bioconjugate Chem., 8, 354-364, (1997).

182 "Solution Structure of an Intramolecular DNA Triplex Containing an N7-Glycosylated Guanine Which Mimics a Protonated Cytosine," Karl M. Koshlap, Peter Schultze, Helmut Brunar, Peter B. Dervan, Juli Feigon.

Biochemistry, 36, 2659-2668, (1997).

181 "Effects of the A·T/T·A Degeneracy of Pyrrole-Imidazole Polyamide Recognition in the Minor Groove of DNA," Sarah White, Eldon E. Baird, Peter B. Dervan.

Biochemistry, 35, 12532-12537, (1996).

180 "Sequence-Specific Alkylation and Cleavage of DNA Mediated by Purine Motif Triple Helix Formation," Kathryn B. Grant, Peter B. Dervan.

Biochemistry, 35, 12313-12319, (1996).

179 "Design of artificial sequence-specific DNA bending ligands," David A. Liberles, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 93, 9510-9514, (1996).

178 "Recognition of a 5'-(A,T)GGG(A,T)2-3' Sequence in the Minor Groove of DNA by an Eight-Ring Hairpin Polyamide," Susanne E. Swalley, Eldon E. Baird, Peter B. Dervan.

J. Am. Chem. Soc., 118, 8198-8206, (1996).

177 "Binding of a hairpin polyamide in the minor groove of DNA: Sequence-specific enthalpic discrimination," Daniel S. Pilch, Nataša Poklar, Craig A. Gelfand, Scott M. Law, Kenneth J. Breslauer, Eldon E. Baird, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 93, 8306-8311, (1996).

176 "Recognition of DNA by designed ligands at subnanomolar concentrations," John W. Trauger, Eldon E. Baird, Peter B. Dervan.

Nature, 382, 559-561, (1996).

175 "Cooperative Triple-Helix Formation via a Minor Groove Dimerization Domain," Jason W. Szewczyk, Eldon E. Baird, Peter B. Dervan.

J. Am. Chem. Soc., 118, 6778-6779, (1996).

174 "Sequence-Specific Recognition of DNA by a Major and Minor Groove Binding Ligand," Jason W. Szewczyk, Eldon E. Baird, Peter B. Dervan.

Angew. Chem. Int. Ed., 35, 1487-1489, (1996).

173 "Binding site size limit of the 2:1 pyrrole-imidazole polyamide-DNA motif," James J. Kelly, Eldon E. Baird, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 93, 6981-6985, (1996).

172 "Extended hairpin polyamide motif for sequence-specific recognition in the minor groove of DNA," John W. Trauger, Eldon E. Baird, Peter B. Dervan.

Chem. Biol., 3, 369-377, (1996).

171 "Extension of Sequence-Specific Recognition in the Minor Groove of DNA by Pyrrole-Imidazole Polyamides to 9-13 Base Pairs," John W. Trauger, Eldon E. Baird, Milan Mrksich, Peter B. Dervan.

J. Am. Chem. Soc., 118, 6160-6166, (1996).

170 "Recognition of 5'-(A,T)GG(A,T)2-3' Sequences in the Minor Groove of DNA by Hairpin Polyamides," Michelle E. Parks, Eldon E. Baird, Peter B. Dervan.

J. Am. Chem. Soc., 118, 6153-6159, (1996).

169 "Optimization of the Hairpin Polyamide Design for Recognition of the Minor Groove of DNA," Michelle E. Parks, Eldon E. Baird, Peter B. Dervan.

J. Am. Chem. Soc., 118, 6147-6152, (1996).

168 "Solid Phase Synthesis of Polyamides Containing Imidazole and Pyrrole Amino Acids," Eldon E. Baird, Peter B. Dervan.

J. Am. Chem. Soc., 118, 6141-6146, (1996).

167 "Simultaneous Binding of a Polyamide Dimer and an Oligonucleotide in the Minor and Major Grooves of DNA," Michelle E. Parks, Peter B. Dervan.

Bioorg. Med. Chem., 4, 1045-1050, (1996).

166 "Sequence composition effects on the stabilities of triple helix formation by oligonucleotiides containing N7-deoxyguanosine," Helmut Brunar, Peter B. Dervan.

Nucleic Acids Res., 24, 1987-1991, (1996).

165 "Solution Structure of a Pyrimidine·Purine·Pyrimidine Triplex Containing the Sequence-specific Intercalating Non-natural Base D3," Edmond Wang, Karl M. Koshlap, Paul Gillespie, Peter B. Dervan, Juli Feigon.

J. Mol. Biol., 257, 1052-1069, (1996).

164 "Extending the recognition site of designed minor groove binding molecules," Bernhard H. Geierstanger, Milan Mrksich, Peter B. Dervan, David E. Wemmer.

Nat. Struct. Biol., 3, 321-324, (1996).

163 "RecA·oligonucleotide filaments bind in the minor groove of double-stranded DNA," Ramesh Baliga, Jennifer W. Singleton, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 92, 10393-10397, (1995).

162 "Cyclic polyamides for recognition in the minor groove of DNA," Junhyeong Cho, Michelle E. Parks, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 92, 10389-10392, (1995).

161 "Only one of the two DNA-bound orientations of AP-1 found in solution cooperates with NFATp," Lin Chen, Martha G. Oakley, J. N. Mark Glover, Jugnu Jain, Peter B. Dervan, Patrick G. Hogan, Anjana Rao, Gregory L. Verdine.

Curr. Biol., 5, 882-889, (1995).

160 "Energetics of Formation of Sixteen Triple Helical Complexes Which Vary at a Single Position within a Purine Motif," William A. Greenberg, Peter B. Dervan.

J. Am. Chem. Soc., 117, 5016-5022, (1995).

159 "Cooperative Triple-Helix Formation at Adjacent DNA Sites: Sequence Composition Dependence at the Junction," Natalia Colocci, Peter B. Dervan.

J. Am. Chem. Soc., 117, 4781-4787, (1995).

158 "Recognition in the Minor Groove of DNA at 5'-(A,T)GCGC(A,T)-3' by a Four Ring Tripeptide Dimer. Reversal of the Specificity of the Natural Product Distamycin," Milan Mrksich, Peter B. Dervan.

J. Am. Chem. Soc., 117, 3325-3332, (1995).

157 "Sequence Composition Effects on the Energetics of Triple Helix Formation by Oligonucleotides Containing a Designed Mimic of Protonated Cytosine," E. Scott Priestley, Peter B. Dervan.

J. Am. Chem. Soc., 117, 4761-4765, (1995).

156 "Design of an N7-Glycosylated Purine Nucleoside for Recognition of GC Base Pairs by Triple Helix Formation," Jürg Hunziker, E. Scott Priestley, Helmut Brunar, Peter B. Dervan.

J. Am. Chem. Soc., 117, 2661-2662, (1995).

155 "Energetics of Formation of Sixteen Triple Helical Complexes Which Vary at a Single Position within a Pyrimidine Motif," George C. Best, Peter B. Dervan.

J. Am. Chem. Soc., 117, 1187-1193, (1994).

154 "Design of a G·C-Specific DNA Minor Groove-Binding Peptide," Bernhard H. Geierstanger, Milan Mrksich, Peter B. Dervan, David E. Wemmer.

Science, 266, 646-650, (1994).

153 "Temperature Dependence of the Energetics of Oligonucleotide-Directed Triple-Helix Formation at a Single DNA Site," Scott F. Singleton, Peter B. Dervan.

J. Am. Chem. Soc., 116, 10376-10382, (1994).

152 "Weak Temperature Dependence of Electron Transfer Rates in Fixed-Distance Porphyrin-Quinone Model Systems," Lutfur R. Khundkar, Joseph W. Perry, James E. Hanson, Peter B. Dervan.

J. Am. Chem. Soc., 116, 9700-9709, (1994).

151 "Mapping RNA Regions in Eukaryotic Ribosomes That Are Accessible to Methidiumpropyl-EDTA·Fe(II) and EDTA·Fe(II)," Hogyu Han, Alanna Schepartz, Maria Pellegrini, Peter B. Dervan.

Biochemistry, 33, 9831-9844, (1994).

150 "Hairpin Peptide Motif. A New Class of Oligopeptides for Sequence-Specific Recognition in the Minor Groove of Double-Helical DNA," Milan Mrksich, Michelle E. Parks, Peter B. Dervan.

J. Am. Chem. Soc., 116, 7983-7988, (1994).

149 "Different conforrmational families of pyrimidine·purine·pyrimidine triple helices depending on backbone composition," Hogyu Han, Peter B. Dervan.

Nucleic Acids Res., 22, 2837-2844, (1994).

148 "Inhibition of Klenow Fragment DNA Polymerase on Double-Helical Templates by Oligonucleotide-Directed Triple-Helix Formation," Joseph G. Hacia, Peter B. Dervan, Barbara J. Wold.

Biochemistry, 33, 6192-6200, (1994).

147 "Sequence specificity of the non-natural pyrido[2,3-d]pyrimidine nucleoside in triple helix formation," Andrea B. Staubli, Peter B. Dervan.

Nucleic Acids Res., 22, 2637-2642, (1994).

146 "Visualization of RNA tertiary structure by RNA-EDTA·Fe(II) autocleavage: Analysis of tRNAPhe with uridine-EDTA·Fe(II) at position 47," Hogyu Han, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 91, 4955-4959, (1994).

145 "Phosphorothioate Oligonucleotide-Directed Triple Helix Formation," Joseph G. Hacia, Barbara J. Wold, Peter B. Dervan.

Biochemistry, 33, 5367-5369, (1994).

144 "Design of a Covalent Peptide Heterodimer for Sequence-Specific Recognition in the Minor Groove of Double-Helical DNA," Milan Mrksich, Peter B. Dervan.

J. Am. Chem. Soc., 116, 3663-3664, (1994).

143 "Synthesis of a Hybrid Protein Containing the Iron-Binding Ligand of Bleomycin and the DNA-Binding Domain of Hin," Martha G. Oakley, Kenneth D. Turnbull, Peter B. Dervan.

Bioconjugate Chem., 5, 242-247, (1994).

142 "Cooperative Binding of 8-mer Oligonucleotides Containing 5-(1-Propynyl)-2'-deoxyuridine to Adjacent DNA Sites by Triple-Helix Formation," Natalia Colocci, Peter B. Dervan.

J. Am. Chem. Soc., 116, 785-786, (1994).

141 "Structural and Dynamic Characterization of the Heterodimeric and Homodimeric Complexes of Distamycin and 1-Methylimidazole-2-carboxamide-Netropsin Bound to the Minor Groove of DNA," Bernhard H. Geierstanger, Jens Peter Jacobsen, Milan Mrksich, Peter B. Dervan, David E. Wemmer.

Biochemistry, 33, 3055-3062, (1994).

140 "Equilibrium Association Constants for Oligonucleotide-Directed Triple Helix Formation at Single DNA Sites: Linkage to Cation Valence and Concentration," Scott F. Singleton, Peter B. Dervan.

Biochemistry, 32, 13171-13179, (1993).

139 "Structural Analysis of Covalent Peptide Dimers, Bis(pyridine-2-carboxamidonetropsin)(CH2)3-6, in Complex with 5'-TGACT-3' Sites by Two-Dimensional NMR," Tammy J. Dwyer, Bernhard H. Geierstanger, Milan Mrksich, Peter B. Dervan, David E. Wemmer.

J. Am. Chem. Soc., 115, 9900-9906, (1993).

138 "Enhanced Sequence Specific Recognition in the Minor Groove of DNA by Covalent Peptide Dimers: Bis(pyridine-2-carboxamidonetropsin)(CH2)3-6," Milan Mrksich, Peter B. Dervan.

J. Am. Chem. Soc., 115, 9892-9899, (1993).

137 "Binding Affinities of Synthetic Peptides, Pyridine-2-carboxamidonetropsin and 1-Methylimidazole-2-carboxamidonetropsin, That Form 2:1 Complexes in the Minor Groove of Double-Helical DNA," Warren S. Wade, Milan Mrksich, Peter B. Dervan.

Biochemistry, 32, 11385-11389, (1993).

136 "NMR Structural Studies on a Nonnatural Deoxyribonucleoside Which Mediates Recognition of GC Base Pairs in Pyrimidine·Purine·Pyrimidine DNA Triplexes," Ishwar Radhakrishnan, Dinshaw J. Patel, E. Scott Priestley, Huw M. Nash, Peter B. Dervan.

Biochemistry, 32, 11228-11234, (1993).

135 "Nonnatural Deoxyribonucleoside D3 Incorporated in an Intramolecular DNA Triplex Binds Sequence-Specifically by Intercalation," Karl M. Koshlap, Paul Gillespie, Peter B. Dervan, Juli Feigon.

J. Am. Chem. Soc., 115, 7908-7909, (1993).

134 "Adenine-Specific DNA Chemical Sequencing Reaction," Brent L. Iverson, Peter B. Dervan.

Methods Enzymol., 218, 222-227, (1993).

133 "A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes," The Huntington's Disease Collaborative Research Group.

Cell, 72, 817-818, (1993).

132 "Cooperative Oligonucleotide-Directed Triple Helix Formation at Adjacent DNA Sites," Natalia Colocci, Mark D. Distefano, Peter B. Dervan.

J. Am. Chem. Soc., 115, 4468-4473, (1993).

131 "Site-Specific Enzymatic Incorporation of an Unnatural Base, N6-(6-Aminohexyl)isoguanosine, into RNA," Yitzhak Tor, Peter B. Dervan.

J. Am. Chem. Soc., 115, 4461-4467, (1993).

130 "Sequence-specific recognition of double helical RNA and RNA·DNA by triple helix formation," Hogyu Han, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 90, 3806-3810, (1993).

129 "Crystallization and Preliminary X-ray Analysis of the DNA Binding Domain of the Hin Recombinase with Its DNA Binding Site," Jin-An Feng, Melvin Simon, David P. Mack, Peter B. Dervan, Reid C. Johnson, Richard E. Dickerson.

J. Mol. Biol., 232, 982-986, (1993).

128 "Antiparallel Side-by-Side Heterodimer for Sequence-Specific Recognition in the Minor Groove of DNA by a Distamycin/1-Methylimidazole-2-carboxamide-netropsin Pair," Milan Mrksich, Peter B. Dervan.

J. Am. Chem. Soc., 115, 2572-2576, (1993).

127 "Energetics of cooperative binding of oligonucleotides with discrete dimerization domains to DNA by triple helix formation," Mark D. Distefano, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 90, 1179-1183, (1993).

126 "Specific Recognition of CG Base Pairs by 2-Deoxynebularine within the Purine·Purine·Pyrimidine Triple-Helix Motif," Hans Ulrich Stilz, Peter B. Dervan.

Biochemistry, 32, 2177-2185, (1993).

125 "Ligand-Promoted Dimerization of Oligonucleotides Binding Cooperatively to DNA," Mark D. Distefano, Peter B. Dervan.

J. Am. Chem. Soc., 114, 11006-11007, (1992).

124 "Influence of pH on the Equilibrium Association Constants for Oligodeoxyribonucleotide-Directed Triple Helix Formation at Single DNA Sites," Scott F. Singleton, Peter B. Dervan.

Biochemistry, 31, 10995-11003, (1992).

123 "Evidence That a Minor Groove-Binding Peptide and a Major Groove-Binding Protein Can Simultaneously Occupy a Common Site on DNA," Martha G. Oakley, Milan Mrksich, Peter B. Dervan.

Biochemistry, 31, 10969-10975, (1992).

122 "Design of Peptides That Bind in the Minor Groove of DNA at 5'-(A,T)G(A,T)C(A,T)-3' Sequences by a Dimeric Side-by-Side Motif," Warren S. Wade, Milan Mrksich, Peter B. Dervan.

J. Am. Chem. Soc., 114, 8783-8794, (1992).

121 "Sequence-Specific Oxidative Cleavage of DNA by a Designed Metalloprotein, Ni(II)·GGH(Hin139-190)," David P. Mack, Peter B. Dervan.

Biochemistry, 31, 9399-9405, (1992).

120 "Reagents for the site-specific cleavage of megabase DNA," Peter B. Dervan.

Nature, 359, 87-88, (1992).

119 "Recognition of All Four Base Pairs of Double-Helical DNA by Triple-Helix Formation: Design of Nonnatural Deoxyribonucleosides for Pyrimidine·Purine Base Pair Binding," Linda C. Griffin, Laura L. Kiessling, Peter A. Beal, Paul Gillespie, Peter B. Dervan.

J. Am. Chem. Soc., 114, 7976-7982, (1992).

118 "Thermodynamics of Oligodeoxyribonucleotide-Directed Triple Helix Formation: An Analysis Using Quantitative Affinity Cleavage Titration," Scott F. Singleton, Peter B. Dervan.

J. Am. Chem. Soc., 114, 6957-6965, (1992).

117 "Nonenzymatic ligation of double-helical DNA by alternate-strand triple helix formation," Kevin J. Luebke, Peter B. Dervan.

Nucleic Acids Res., 20, 3005-3009, (1992).

116 "Antiparallel side-by-side dimeric motif for sequence-specific recognition in the minor groove of DNA by the designed peptide 1-methylimidazole-2-carboxamide netropsin," Milan Mrksich, Warren S. Wade, Tammy J. Dwyer, Bernhard H. Geierstanger, David E. Wemmer, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 89, 7586-7590, (1992).

115 "The influence of single base triplet changes on the stability of a Pur·Pur·Pyr triple helix determined by affinity cleaving," Peter A. Beal, Peter B. Dervan.

Nucleic Acids Res., 20, 2773-2776, (1992).

114 "Sequence-Specific Double-Strand Alkylation and Cleavage of DNA Mediated by Triple-Helix Formation," Thomas J. Povsic, Scott A. Strobel, Peter B. Dervan.

J. Am. Chem. Soc., 114, 5934-5941, (1992).

113 "Recognition of Double Helical DNA by Alternate Strand Triple Helix Formation," Peter A. Beal, Peter B. Dervan.

J. Am. Chem. Soc., 114, 4976-4982, (1992).

112 "Flanking Sequence Effects within Pyrimidine Triple-Helix Motif Characterized by Affinity Cleaving," Laura L. Kiessling, Linda C. Griffin, Peter B. Dervan.

Biochemistry, 31, 2829-2834, (1992).

111 "Design of a Nonnatural Deoxyribonucleoside for Recognition of GC Base Pairs by Oligonucleotide-Directed Triple Helix Formation," Jong Sung Koh, Peter B. Dervan.

J. Am. Chem. Soc., 114, 1470-1478, (1992).

110 "Analysis of Promoter-Specific Repression by Triple-Helical DNA Complexes in a Eukaryotic Cell-Free Transcription System," L. James Maher, III, Peter B. Dervan, Barbara Wold.

Biochemistry, 31, 70-81, (1992).

109 "Triple Helix-Mediated Single-Site Enzymatic Cleavage of Megabase Genomic DNA," Scott A. Strobel, Peter B. Dervan.

Methods Enzymol., 216, 309-321, (1992).

108 "Site-Specific Cleavage of Human Chromosome 4 Mediated by Triple-Helix Formation," Scott A. Strobel, Lynn A. Doucette-Stamm, Laura Riba, David E. Housman, Peter B. Dervan.

Science, 254, 1639-1642, (1991).

107 "Orientation of the Lac repressor DNA binding domain in complex with the left lac operator half site characterized by affinity cleaving," Jumi A. Shin, Richard H. Ebright, Peter B. Dervan.

Nucleic Acids Res., 19, 5233-5236, (1991).

106 "Effects of an abasic site on triple helix formation characterized by affinity cleaving," David A. Horne, Peter B. Dervan.

Nucleic Acids Res., 19, 4963-4965, (1991).

105 "Nonenzymatic Sequence-Specific Ligation of Double-Helical DNA," Kevin J. Luebke, Peter B. Dervan.

J. Am. Chem. Soc., 113, 7447-7448, (1991).

104 "Cooperative Binding of Oligonucleotides to DNA by Triple Helix Formation: Dimerization via Watson-Crick Hydrogen Bonds," Mark D. Distefano, Jumi A. Shin, Peter B. Dervan.

J. Am. Chem. Soc., 113, 5901-5902, (1991).

103 "Second Structural Motif for Recognition of DNA by Oligonucleotide-Directed Triple-Helix Formation," Peter A. Beal, Peter B. Dervan.

Science, 251, 1360-1363, (1991).

102 "Single-site enzymatic cleavage of yeast genomic DNA mediated by triple helix formation," Scott A. Strobel, Peter B. Dervan.

Nature, 350, 172-174, (1991).

101 "Characterization of protein-DNA complexes by affinity cleaving," Peter B. Dervan.

Methods Enzymol., 208, 497-515, (1991).

100 "Thermodynamic characterization of the stability and the melting behavior of a DNA triplex: A spectroscopic and calorimetric study," G. Eric Plum, Young-Whan Park, Scott F. Singleton, Peter B. Dervan, Kenneth J. Breslauer.

Proc. Natl. Acad. Sci. USA, 87, 9436-9440, (1990).

99 "Sequence-Specific Alkylation of Double-Helical DNA by Oligonucleotide-Directed Triple-Helix Formation," Thomas J. Povsic, Peter B. Dervan.

J. Am. Chem. Soc., 112, 9428-9430, (1990).

98 "Single-Strand DNA Triple-Helix Formation," Robert Häner, Peter B. Dervan.

Biochemistry, 29, 9761-9765, (1990).

97 "Kinetic Analysis of Oligodeoxyribonucleotide-Directed Triple-Helix Formation on DNA," L. James Maher, III, Peter B. Dervan, Barbara J. Wold.

Biochemistry, 29, 8820-8826, (1990).

96 "Structural Motif of the DNA Binding Domain of γδ-Resolvase Characterized by Affinity Cleaving," Kenneth S. Graham, Peter B. Dervan.

J. Biol. Chem., 265, 16534-16540, (1990).

95 "Reagents and Methods for the Solid-Phase Synthesis of Protein-EDTA for Use in Affinity Cleaving," James P. Sluka, John H. Griffin, David P. Mack, Peter B. Dervan.

J. Am. Chem. Soc., 112, 6369-6374, (1990).

94 "Site-Specific Cleavage of a Yeast Chromosome by Oligonucleotide-Directed Triple-Helix Formation," Scott A. Strobel, Peter B. Dervan.

Science, 249, 73-75, (1990).

93 "Orientation of the Putative Recognition Helix in the DNA-Binding Domain of Hin Recombinase Complexed with the Hix Site," David P. Mack, James P. Sluka, Jumi A. Shin, John H. Griffin, Melvin I. Simon, Peter B. Dervan.

Biochemistry, 29, 6561-6567, (1990).

92 "Importance of Minor-Groove Contacts for Recognition of DNA by the Binding Domain of Hin Recombinase," James P. Sluka, Suzanna J. Horvath, Anna C. Glasgow, Melvin I. Simon, Peter B. Dervan.

Biochemistry, 29, 6551-6561, (1990).

91 "Structural Motif of the GCN4 DNA Binding Domain Characterized by Affinity Cleaving," Martha G. Oakley, Peter B. Dervan.

Science, 248, 847-850, (1990).

90 "Nickel-Mediated Sequence-Specific Oxidative Cleavage of DNA by a Designed Metalloprotein," David P. Mack, Peter B. Dervan.

J. Am. Chem. Soc., 112, 4604-4606, (1990).

89 "Recognition of Mixed-Sequence Duplex DNA by Alternate-Strand Triple-Helix Formation," David A. Horne, Peter B. Dervan.

J. Am. Chem. Soc., 112, 2435-2437, (1990).

88 "Chemical Methods for the Site-Specific Cleavage of Genomic DNA," Peter B. Dervan.

Structure & Methods Vol. 1: Human Genome Initiative & DNA Recombination (R. H. Sarma and M. H. Sarma, (eds.)), 37-49, Adenine Press, (1990).

87 "Oligonucleotide Recognition of Double Helical DNA by Triple Helix Formation," Peter B. Dervan.

Oligonucleotides as Inhibitors of Gene Expression (J. S. Cohen (ed.)), 197-210, MacMillan Press Ltd., London, (1990).

86 "Nonenzymatic Ligation of Oligodeoxyribonucleotides on a Duplex DNA Template by Triple-Helix Formation," Kevin J. Luebke, Peter B. Dervan.

J. Am. Chem. Soc., 111, 8733-8735, (1989).

85 "Recognition of Thymine·Adenine Base Pairs by Guanine in a Pyrimidine Triple Helix Motif," Linda C. Griffin, Peter B. Dervan.

Science, 245, 967-971, (1989).

84 "Inhibition of DNA Binding Proteins by Oligonucleotide-Directed Triple Helix Formation," Louis J. Maher III, Barbara Wold, Peter B. Dervan.

Science, 245, 725-730, (1989).

83 "Cooperative Site Specific Binding of Oligonucleotides to Duplex DNA," Scott A. Strobel, Peter B. Dervan.

J. Am. Chem. Soc., 111, 7286-7287, (1989).

82 "Interactions Between a Symmetrical Minor Groove Binding Compound and DNA Oligonucleotides: 1H and 19F NMR Studies," Andrew H.-J. Wang, Sylvain Cottens, Peter B. Dervan, James P. Yesinowski, Gijs A. van der Marel, Jacques H. van Boom.

Journal of Biomolecular Structure and Dynamics, 7, 101-117, (1989).

81 "Specific Activation of Open Complex Formation at an Escherichia coli Promoter by Oligo(N-methylpyrrolecarboxamide)s: Effects of Peptide Length and Identification of DNA Target Sites," Pamela A. Martello, James P. Bruzik, Pieter deHaseth, R. Scott Youngquist, Peter B. Dervan.

Biochemistry, 28, 4455-4461, (1989).

80 "Triple Helix Formation by Oligonucleotides on DNA Extended to the Physiological pH Range," Thomas J. Povsic, Peter B. Dervan.

J. Am. Chem. Soc., 111, 3059-3061, (1989).

79 "Sequence-Specific Cleavage of DNA by N-Bromoacetyldistamycin. Product and Kinetic Analyses," Brenda F. Baker, Peter B. Dervan.

J. Am. Chem. Soc., 111, 2700-2712, (1989).

78 "Metalloregulation in the Sequence Specific Binding of Synthetic Molecules to DNA," J. H. Griffin, Peter B. Dervan.

Metal Ion Homeostasis: Molecular Biology and Chemistry (D. H. Hamer, D. R. Winge (eds.)), 98, 21-30, A. R. Liss, Inc., New York, (1989).

77 "Double-Strand Cleavage of Genomic DNA at a Single Site by Triple-Helix Formation," Scott A. Strobel, Heinz E. Moser, Peter B. Dervan.

J. Am. Chem. Soc., 110, 7927-7929, (1988).

76 "Design and Chemical Synthesis of a Sequence-Specific DNA-Cleaving Protein," David P. Mack, Brent L. Iverson, Peter B. Dervan.

J. Am. Chem. Soc., 110, 7572-7574, (1988).

75 "John D. Roberts," Peter B. Dervan.

Aldrichimica Acta, 21, 71-77, (1988).

74 "The Origins of the DNA Binding Affinity and Specificity of Minor Groove Directed Ligands: Correlations of Thermodynamic and Structural Data," Kenneth J. Breslauer, R. Ferrante, L. A. Marky, Peter B. Dervan, R. Scott Youngquist.

Structure and Expression, DNA and Its Drug Complexes (R. H. Sarma and M. H. Sarma (eds.)), 2, 273-289, Academic Press, (1988).

73 "Synthetic Tools for Molecular Biology," Peter B. Dervan.

Biotechnology and Materials Science, 21-29, ACS Press, Washington, D. C, (1988).

72 "Nonenzymatic sequence-specific methyl transfer to single-stranded DNA," Brent L. Iverson, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 85, 4615-4619, (1988).

71 "Sequence Specific Recognition of Double Helical DNA. A Synthetic Approach," Peter B. Dervan.

Nucleic Acids and Molecular Biology (F. Eckstein and D. M. J. Lilley (eds.)), 2, 49-64, Springer-Verlag, Heidelberg, (1988).

70 "Sequence Specific Recognition and Cleavage of Double Helical DNA," Peter B. Dervan.

The Robert A. Welch Foundation Conference on Chemical Research XXXI. Design of Enzymes and Enzyme Models, 93-109, , Houston, Texas, (1987).

69 "A Synthetic Peptide Binds 16 Base Pairs of A,T Double Helical DNA," R. Scott Youngquist, Peter B. Dervan.

J. Am. Chem. Soc., 109, 7564-7566, (1987).

68 "Synthesis of a Sequence-Specific DNA-Cleaving Peptide," James P. Sluka, Suzanna J. Horvath, Michael F. Bruist, Melvin I. Simon, Peter B. Dervan.

Science, 238, 1129-1132, (1987).

67 "Sequence-Specific Cleavage of Double Helical DNA by Triple Helix Formation," Heinz E. Moser, Peter B. Dervan.

Science, 238, 645-650, (1987).

66 "Adenine specific DNA chemical sequencing reaction," Brent L. Iverson, Peter B. Dervan.

Nucleic Acids Res., 15, 7823-7830, (1987).

65 "Metalloregulation in the Sequence Specific Binding of Synthetic Molecules to DNA," John H. Griffin, Peter B. Dervan.

J. Am. Chem. Soc., 109, 6840-6842, (1987).

64 "Effect of exothermicity on electron transfer rates in photosynthetic molecular models," A. D. Joran, B. A. Leland, P. M. Felker, A. H. Zewail, J. J. Hopfield, P. B. Dervan.

Nature, 327, 508-511, (1987).

63 "Alteration of the Sequence Specificity of Distamycin on DNA by Replacement of an N-Methylpyrrolecarboxamide with Pyridine-2-carboxamide," Warren S. Wade, Peter B. Dervan.

J. Am. Chem. Soc., 109, 1574-1575, (1987).

62 "Nonezymatic Sequence-Specific Cleavage of Single-Stranded DNA to Nucleotide Resolution. DNA Methyl Thioether Probes," Brent L. Iverson, Peter B. Dervan.

J. Am. Chem. Soc., 109, 1241-1243, (1987).

61 "Hoogsteen base pairs proximal and distal to echinomycin binding sites on DNA," David Mendel, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 84, 910-914, (1987).

60 "Design of Synthetic Sequence Specific DNA Binding Molecules," Peter B. Dervan.

Molecular Mechanisms of Carcinogenic and Antitumor Activity (C. Chagas and B. Pullman, Ed.,), 365-384, Study Group Meeting, Pontifical Academy of Science, Vatican, (1986).

59 "Synthetic Sequence Specific DNA Binding Molecules," Peter B. Dervan, R. Scott Youngquist, James P. Sluka.

Stereochemistry of Organic and Bioorganic Transformations (W. Bartmann and K. B. Sharpless (eds.)), Verlag Chemie, Weinheim, (1986).

58 "Sequence-Specific Chiral Recognition of Right-Handed Double-Helical DNA by (2S,3S)- and (2R,3R)-Dihydroxybis(netropsin)succinamide," John H. Griffin, Peter B. Dervan.

J. Am. Chem. Soc., 108, 5008-5009, (1986).

57 "Design of Sequence-Specific DNA-Binding Molecules," Peter B. Dervan.

Science, 232, 464-471, (1986).

56 "Design of Sequence Specific DNA Binding Molecules: Bis(distamycin)-phenoxazone.," Peter B. Dervan, James P. Sluka.

Internat. Kyoto Conf. on Org. Chem. Proceedings, "New Synthetic Methodology and Functionally Interesting Compounds.", 307-322, Elsevier Scientific Publishing Co and Kodanska Ltd, Tokyo, (1986).

55 "Design of Sequence-specific DNA Cleaving Molecules: Comparison of Distamycin-EDTA·Fe(II) and N-Bromoacetyldistamycin," Peter B. Dervan, Brenda F. Baker.

Ann. N. Y. Acad. Sci., 471, 51-59, (1986).

54 "Picosecond Fluorexcence Studies on Intramolecular Photochemical Electron Transfer in Porphyrins Linked to Quinones at Two Different Fixed Distances," B. A. Leland, A. D. Joran, P. M. Felker, J. J. Hopfield, A. H. Zewail, P. B. Dervan.

J. Phys. Chem., 89, 5571-5573, (1985).

53 "Comparison of synthetic psoralen derivatives and 8-MOP in the inhibition of lymphocyte proliferation," C. L. Berger, C. Cantor, J. Welsh, P. Dervan, T. Begley, S. Grant, F. P. Gasparro, R. L. Edelson.

Ann. N. Y. Acad. Sci., 453, 80-90, (1985).

52 "Sequence-Specific Cleavage of Double-Helical DNA. N-Bromoacetyldistamycin," Brenda F. Baker, Peter B. Dervan.

J. Am. Chem. Soc., 107, 8266-8268, (1985).

51 "Sequence-Specific Recognition of B-DNA by Bis(EDTA-distamycin)fumaramide," R. Scott Youngquist, Peter B. Dervan.

J. Am. Chem. Soc., 107, 5528-5529, (1985).

50 "Molecular recognition of B-DNA by Hoechst 33258," Keith D. Harshman, Peter B. Dervan.

Nucleic Acids Res., 13, 4825-4835, (1985).

49 "Sequence-specific recognition of B-DNA by oligo(N-methylpyrrolecarboxamide)s," R. Scott Youngquist, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 82, 2565-2569, (1985).

48 "Sequence-specific cleavage of single-stranded DNA: Oligodeoxynucleotide-EDTA·Fe(II)," Geoffrey B. Dreyer, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 82, 968-972, (1985).

47 "Models for Photochemical Electron Transfer at Fixed Distances. Porphyrin-Bicyclo[2.2.2]octane-Quinone and Porphyrin-Bibicyclo[2.2.2]octane-Quinone," Alvin D. Joran, Burton A. Leland, George G. Geller, John J. Hopfield, Peter B. Dervan.

J. Am. Chem. Soc., 106, 6090-6092, (1984).

46 "Echinomycin Binding Sites on DNA," Michael M. Van Dyke, Peter B. Dervan.

Science, 225, 1122-1127, (1984).

45 "Low-Temperature Matrix Isolation of H2NN. Electronic and Infrared Characterization," Alan P. Sylwester, Peter B. Dervan.

J. Am. Chem. Soc., 106, 4648-4650, (1984).

44 "Cleavage of DNA with Methidiumpropyl-EDTA·Fe(II): Conditions and Product Analyses," Robert P. Hertzberg, Peter B. Dervan.

Biochemistry, 23, 3934-3945, (1984).

43 "Distamycin and Penta-N-Methylpyrrolecarboxamide Binding Sites on Native DNA A Comparison of Methidiumpropyl-EDTA·Fe(II) Footprinting and DNA Affinity Cleaving," Peter G. Schultz, Peter B. Dervan.

Journal of Biomolecular Structure and Dynamics, 1, 1133-1147, (1984).

42 "DNA Affinity Cleaving. Sequence Specific Cleavage of DNA by Distamycin-EDTA·Fe(II) and EDTA-Distamycin·Fe(II)," John S. Taylor, Peter G. Schultz, Peter B. Dervan.

Tetrahedron, 40, 457-465, (1984).

41 "Sequence-Specific Double-Strand Cleavage of DNA by Bis(EDTA-distamycin·FeII) and EDTA-Bis(distamycin)·FeII," Peter G. Schultz, Peter B. Dervan.

J. Am. Chem. Soc., 105, 7748-7750, (1983).

40 "Sequence-specific double-strand cleavage of DNA by penta-N-methylpyrrolecarboxamide-EDTA·Fe(II)," Peter G. Schultz, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 80, 6834-6837, (1983).

39 "Methidiumpropyl-EDTA·Fe(II) and DNase I footprinting report different small molecule binding site sizes on DNA," Michael W. Van Dyke, Peter B. Dervan.

Nucleic Acids Res., 11, 5555-5567, (1983).

38 "Cleavage of chromatin with methidiumpropyl-EDTA·iron(II)," Iain L. Cartwright, Robert P. Hertzberg, Peter B. Dervan, Sarah C. R. Elgin.

Proc. Natl. Acad. Sci. USA, 80, 3213-3217, (1983).

37 "Chromomycin, Mithramycin, and Olivomycin Binding Sites on Heterogeneous Deoxyribonucleic Acid. Footprinting with (Methidiumpropyl-EDTA)iron(II)," Michael W. Van Dyke, Peter B. Dervan.

Biochemistry, 22, 2373-2377, (1983).

36 "Evidence for a Stereospecific 1,2-Elimination Reaction in a 1,1-Diazene. Synthesis and Decomposition of [N-Phenyl(threo-(and erythro)-2-deuterio-1-methylpropyl)amino]nitrene," Daniel C. Duan, Peter B. Dervan.

J. Org. Chem., 48, 970-976, (1983).

35 "Footprinting with MPE·Fe(II). Complementary-strand Analyses of Distamycin- and Actinomycin-binding Sites on Heterogeneous DNA," Michael W. Van Dyke, Peter B. Dervan.

Cold Spring Harbor Symp. Quant. Biol., 47, 347-353, (1983).

34 "Design and Synthesis of a Sequence-Specific DNA Cleaving Molecule. (Distamycin-EDTA)iron(II)," Peter G. Schultz, John S. Taylor, Peter B. Dervan.

J. Am. Chem. Soc., 104, 6861-6863, (1982).

33 "Photochemistry of 1,1-Diazenes. Direct and Sensitized Photolyses of N-(2,2,5,5-Tetramethylpyrrolidyl)nitrene, dl-N-(2,5-Diethyl-2,5-dimethylpyrrolidyl)nitrene, and N-(2,2,," Peter G. Schultz, Peter B. Dervan.

J. Am. Chem. Soc., 104, 6660-6668, (1982).

32 "1,1-Di-tert-butyldiazene," Daniel K. McIntyre, Peter B. Dervan.

J. Am. Chem. Soc., 104, 6466-6468, (1982).

31 "Map of distamycin, netropsin, and actinomycin binding sites on heterogeneous DNA: DNA cleavage-inhibition patterns with methidiumpropyl-EDTA·Fe(II)," Michael W. Van Dyke, Robert P. Hertzberg, Peter B. Dervan.

Proc. Natl. Acad. Sci. USA, 79, 5470-5474, (1982).

30 "Interhelical DNA-DNA Cross-linking. Bis(monoazidomethidium)octaoxahexacosanediamine: A Probe of Packaged Nucleic Acid," Mark A. Mitchell, Peter B. Dervan.

J. Am. Chem. Soc., 104, 4265-4266, (1982).

29 "Non-Conjugated Diradicals," Peter B. Dervan, Dennis A. Dougherty.

Diradicals, W. Borden, Ed., Academic Press, New York, N. Y., (1982).

28 "Direct Studies of 1,1-Diazenes. Syntheses, Infrared and Electronic Spectra, and Kinetics of the Thermal Decomposition of N-(2,2,6,6-Tetramethylpiperidyl)nitrene and N-(2,2,5,5-Tetrameth," William D. Hinsberg, III, Peter G. Schultz, Peter B. Dervan.

J. Am. Chem. Soc., 104, 766-773, (1982).

27 "Cleavage of Double Helical DNA by (Methidiumpropyl-EDTA)iron(II)," Robert P. Hertzberg, Peter B. Dervan.

J. Am. Chem. Soc., 104, 313-315, (1982).

26 "Sequence-Selective Inhibition of Restriction Endonucleases by the Polyintercalator Bis(methidium)spermine," Richard A. Ikeda, Peter B. Dervan.

J. Am. Chem. Soc., 104, 296-297, (1982).

25 "Photochemistry of a 1,1-Diazene, N-(2,2,5,5-Tetramethylpyrrolidinyl)nitrene," Peter G. Schultz, Peter B. Dervan.

J. Am. Chem. Soc., 103, 1563-1564, (1981).

24 "15N NMR Spectrum of a 1,1-Diazene. N-(2,2,6,6-Tetramethylpiperidyl)nitrene," Peter B. Dervan, Michael E. Squillacote, Paul M. Lahti, Alan P. Sylwester, John D. Roberts.

J. Am. Chem. Soc., 103, 1120-1122, (1981).

23 "Synthesis and Thermal Decomposition of cis-3,4,5,6-Tetrahydropyridazine-3,4-d2. Relative Rates of Rotation, Cleavage, and Closure for Tetramethylene.," Peter B. Dervan, Donald S. Santilli.

J. Am. Chem. Soc., 102, 3863-3870, (1980).

22 "Synthesis and Direct Spectroscopic Observation of N-(2,2,5,5-Tetramethylpyrrolidyl)nitrene. Comparison of Five- and Six-Membered Cyclic 1,1-Dialkyldiazenes," Peter G. Schultz, Peter B. Dervan.

J. Am. Chem. Soc., 102, 878-880, (1980).

21 "Kinetics of the Thermal Decomposition of a 1,1-Dialkyldiazene, N-(2,2,6,6-Tetramethylpiperidyl)nitrene," William D. Hinsberg, III, Peter B. Dervan.

J. Am. Chem. Soc., 101, 6142-6144, (1979).

20 "Molecular Recognition of Nucleic Acid by Small Molecules. Binding Affinity and Structural Specificity of Bis(methidium)spermine," Michael McClellan Becker, Peter B. Dervan.

J. Am. Chem. Soc., 101, 3664-3666, (1979).

19 "Thermal Decomposition of cis-Tetrahydropyridazine- 3,4-d2. Relative Rates of Rotation, Cleavage, and Closure for Tetramethylene," Donald S. Santilli, Peter B. Dervan.

J. Am. Chem. Soc., 101, 3663-3664, (1979).

18 "Syntheses and Decomposition of meso- and dl-2,3-Dimethylsuccinyl and cis- and trans-1,2-Hexahydrophthaloyl Peroxides," Peter B. Dervan, Carol R. Jones.

J. Org. Chem., 44, 2116-2122, (1979).

17 "Stereochemical Tests of Cyclic 1,1-Dialkyldiazene Fragmentation Reactions. Thermal Decomposition of N-(cis-(and trans-(2,3-(and 2,5-)Dimethylpyrrolidine)-nitrenes," Peter B. Dervan, Tadao Uyehara.

J. Am. Chem. Soc., 101, 2076-2082, (1979).

16 "Experimental Determination of the Relative Rates of Rotation, Cleavage, Closure, and 1,5-Hydrogen Shift for 3-Methyl-1,4-pentanediyl. Evidence for 1,4 Biradicals as Common Intermediates from Differen," Peter B. Dervan, Tadao Uyehara, Donald S. Santilli.

J. Am. Chem. Soc., 101, 2069-2075, (1979).

15 "Molecular Recognition of DNA by Small Molecules. Synthesis of Bis(methidium)spermine, a DNA Polyintercalating Molecule," Peter B. Dervan, Michael M. Beckker.

J. Am. Chem. Soc., 100, 1968-1970, (1978).

14 "Synthesis and Direct Spectroscopic Observation of a 1,1-Dialkyldiazene. Infrared and Electronic Spectrum of N-(2,2,6,6-Tetramethylpiperidyl)nitrene," William D. Hinsberg, III, Peter B. Dervan.

J. Am. Chem. Soc., 100, 1608-1610, (1978).

13 "Six-Membered Cyclic Diacyl Peroxide Fragmentations. Thermal Decomposition of meso- and di-2,3-Dimethylsuccinoyl Peroxides," Carol R. Jones, Peter B. Dervan.

J. Am. Chem. Soc., 99, 6772-6774, (1977).

12 "Trimethylsilyl Anions. Direct Synthesis of Trimethylsilylbenzenes," Michael A. Shippey, Peter B. Dervan.

J. Org. Chem., 42, 2654-2655, (1977).

11 "7-Azabicyclo[2.2.1]heptane N-Imide as an Intermediate in the Thermal Decomposition of N-Amino-7-azabicyclo[2.2.1]heptane and the Corresponding Benzenesulphonamide," Peter B. Dervan, Tadao Uyehara.

J. C. S. Chem. Comm., 469-470, (1976).

10 "A Stereochemical Test of Similarly Substituted Tetramethylenediazene and Cyclic Azo Decompositions in the Gas Phase at the Same Temperature," Peter B. Dervan, Tadao Uyehara.

J. Am. Chem. Soc., 98, 2003-2005, (1976).

9 "Trimethylsilylpotassium. Deoxygenation of Epoxides with Inversion of Stereochemistry," Peter B. Dervan, Michael A. Shippey.

J. Am. Chem. Soc., 98, 1265-1267, (1976).

8 "Thermal Decomposition of cis- and trans-3,4- and -3,6-Dimethyl-3,4,5,6-tetrahydropyridazines. Evidence against the Hot Diradical Postulate for Azo Decompositions," Peter B. Dervan, Tadao Uyehara.

J. Am. Chem. Soc., 98, 1262-1264, (1976).

7 "Formation and Thermal Rearrangements of Some Dimers of Butadiene and Piperylene. Tests of the Validity of Thermochemical-Kinetic Arguments for Identification of Common Biradical Intermediates," Jerome A. Berson, Peter B. Dervan, Roger Malherbe, Jerry A. Jenkins.

J. Am. Chem. Soc., 98, 5937-5968, (1976).

6 "A Mechanistic Analysis of the Four Pathways in the 1,3-Sigmatropic Rearrangements of trans-1,2-trans,trans- and trans-1,2-cis,trans-Dipropenylcyclobutane," Jerome A. Berson, Peter B. Dervan.

J. Am. Chem. Soc., 95, 269-270, (1973).

5 "Rearrangement of trans-1,2-Divinylcyclobutane and the Energy Surface of the Dimers of Butadiene," Jerome A. Berson, Peter B. Dervan.

J. Am. Chem. Soc., 95, 267-269, (1973).

4 "The Stereodistal Cope Rearrangement of trans-1,2-Dialkenylcyclobutanes," Jerome A. Berson, Peter B. Dervan.

J. Am. Chem. Soc., 94, 8949-8950, (1972).

3 "The Stereospecific Double Rearrangement of trans-3,4-Dimethyl-cis,trans-cycloocta-1,5-diene to cis-3,4-Dimethyl-cis,cis-cycloocta-1,5-diene," Jerome A. Berson, Peter B. Dervan, Jerry A. Jenkins.

J. Am. Chem. Soc., 94, 7598-7599, (1972).

2 "Incremental Substituent Effects Leading to Steric Blockade of the Boat-Like Six-Center Cope Rearrangement of cis-1,2-Dialkenylcyclobutanes," Jerome A. Berson, Peter B. Dervan.

J. Am. Chem. Soc., 94, 7597-7598, (1972).

1 "Hydroxide Displacement of the Sulfone Linkage in Thioxanthen-9-one 10,10-Dioxides to Benzophenone-2'-hydroxy-2-sulfinic Acids. Intramolecular Cyclization to Xanthones," O. Francis Bennett, M. J. Bouchard, Richard Malloy, Peter Dervin, Gerald Saluti.

J. Org. Chem., 37, 1356-1359, (1972).